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ProteomicsChemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity
Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the Fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular origins of tox...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047056 | Pride
Fluoroquinolones Side-effects Off-targets Chemical proteomics Proteomics Antibiotics 
GenomicsMassively targeted evaluation of therapeutic CRISPR off-targets in cells
Massively targeted evaluation of therapeutic CRISPR off-targets in cells
PRJNA850372 | ENA
ProteomicsChemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity
Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the Fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular origins of tox...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056813 | Pride
Human Full proteome Timstof pro 
GenomicsOn/Off targets INDEL analysis by Next Generation Sequencing
On/Off targets INDEL analysis by Next Generation Sequencing
PRJNA746584 | ENA
GenomicsGenome-wide identification of CRISPR/Cas9 off-targets in human genome
By a robust unbiased ChIP-seq approach, we demonstrated that CRISPR/Cas9 had crRNA-specific off-target binding activities in human genome. However, most of those binding off-targets could not be efficiently cleaved both in vivo and in vitro which suggested the cleavage off-target activity of CRISPR/...
ORGANISM(S): Homo sapiens 
2014-06-18 | GSE58511 | GEO
UnknownPrediction of base editor off-targets by deep learning.
Not available
S-EPMC10475126 | biostudies-literature
GenomicsGenome-wide identification of CRISPR/Cas9 off-targets in human genome
By a robust unbiased ChIP-seq approach, we demonstrated that CRISPR/Cas9 had crRNA-specific off-target binding activities in human genome. However, most of those binding off-targets could not be efficiently cleaved both in vivo and in vitro which suggested the cleavage off-target activity of CRISPR/...
ORGANISM(S): Homo sapiens 
2014-06-18 | E-GEOD-58511 | biostudies-arrayexpress
GenomicsCRISPR-SKIP: Programmable Gene Splicing with Single Base Editors [off-targets]
CRISPR-SKIP: Programmable Gene Splicing with Single Base Editors [off-targets]
PRJNA437655 | ENA
GenomicsRNA-Seq of different TadA variants to validate RNA Off-Targets
RNA-Seq of different TadA variants to validate RNA Off-Targets
PRJNA1086170 | ENA
ProteomicsLive cell tracking of Niraparib off-targets using photo affinity labelling
Explore off-targets of Niraparib in live cells using photo affinity labelling (PAL)
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044331 | Pride
Pal Niraparib Parp Olaparib 
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