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ProteomicsLoss of Cullin 5 in myeloid cells protects against autoimmune neuroinflammation
Autoimmune neuroinflammation occurs when an individual’s immune cells attack the brain, spinal cord or peripheral nerves. Several Suppressor of Cytokine Signaling (SOCS) proteins have been shown to limit pro-inflammatory signaling pathways in myeloid cells and prevent neuroinflammation. They rely on...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD066533 | Pride
T cell activation Cul5 Sh2 domain Cytokine signaling 
ProteomicsNdfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
Project abstract: Foxp3+ T regulatory (Treg) cells have important functions in suppressing immune cell activation and establishing normal immune homeostasis. How Treg cells maintain their identity is not completely understood. Here we show that Ndfip1, a co-activator of Nedd4-family E3 ubiquitin lig...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-19 | PXD006251 | Pride
Effector-type regulatory t cells (etreg cells) Ndfip1 Central regulatory t cells (ctreg cells) Regulatory t cells (treg cells) 
ProteomicsCul5 regulates CD4+ T cell fate choice and allergic inflammation
Antigen encounter directs CD4+ T cells to differentiate into T-helper or -regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern -helper versus -regulatory fate remain poorly understood. Here, we show that the E3 ubiquitin...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD028492 | Pride
Cis T-cell Asthma Allergy Cul5 Crl5 Cd4 Ubiquitin 
ProteomicsThe E3 Ubiquitin Ligase Cul5 Limits HSPC Expansion and Myeloproliferative Disease in Mice
Myeloproliferative Neoplasms (MPNs) are a heterogenous group of hematologic cancers characterized by excessive JAK/STAT signaling. Mutations of JAK2 signaling components are among the most common drivers of MPN, but alterations in Suppressors of Cytokine Signaling (SOCS) proteins have been implicate...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD046958 | Pride
Myeloproliferative neoplasms Jak2 signaling Hspc expansion Cul5 E3 ubiquitin ligase 
Proteomicsc-Myc uses Cul4b to preserve genome stability and promote CD8+ T cell-mediated antiviral immune responses
During infection, virus-specific CD8+ T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus infected cells and reduce viral load. This rapid clonal expansion can put T cells at significant risk for replication-induced DNA damage. We found that c-Myc util...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-29 | PXD041220 | Pride
C-myc Cd8+ t cells Replication stress Antiviral immune responses E3 ubiquitin ligases Cul4b 
UnknownOutcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis.
Not available
S-EPMC10278789 | biostudies-literature
UnknownDesign and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial.
Not available
S-EPMC6889917 | biostudies-literature
UnknownDesign and Baseline Characteristics of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease Trial.
Not available
S-EPMC6888890 | biostudies-literature
UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Not available
S-EPMC11658795 | biostudies-literature
UnknownHealth Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA.
Not available
S-EPMC12492304 | biostudies-literature
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