Sort   by:  
 Page size 
GenomicsCBFb Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression [ChIP-seq]
The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 (A3) family of restriction factors. Recently, the cellular transcription cofactor CBFb was shown to form a complex with CRL5-Vif and to be essential for A3 degradation and vir...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-GEOD-42575 | biostudies-arrayexpress
ProteomicsA3G-Vif-CBFB-CRL5 Cross-Linking with DSSO
Here we use an optimization cross-linking mass spectrometry (XL-MS) pipeline for the structural characterization of a dynamic HIV-host protein complex. Using DSSO-based XL-MS analysis, residue-protein proximity restraints based on functional genetics, and integrative modeling, we define the structu...
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 
2021-11-03 | PXD025391 | Pride
Xl-ms Dsso Apobec3g Hiv vif Integrative modeling 
ProteomicsDisruption of the CRL5 ubiquitin ligase complex enhances engineered T cell persistence under chronic tumor antigen exposure
Engineered T cell therapies are limited by progressive dysfunction under chronic tumor antigen exposure, and genetic perturbation of negative regulators of T cell function has emerged as a promising strategy to sustain long-term effector activity. We reanalyzed a genome-wide CRISPR knockout screen i...
ORGANISM(S): Homo sapiens (Human) 
2026-09-18 | PXD078896 | Pride
Tmt T-cell Crl5 Ubiquitin 
UnknownCRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
Not available
S-EPMC7502717 | biostudies-literature
UnknownCRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
Not available
S-EPMC6138441 | biostudies-literature
TranscriptomicsCRL5-WSB2 Inactivation Drives BIM/NOXA-Mediated Neuronal Apoptosis in Luo-Agrawal Syndrome
Biallelic mutations in WSB2 have recently been linked to Luo-Agrawal syndrome, a newly recognized neurodevelopmental disorder characterized by severe microcephaly and brain hypoplasia; however, the precise molecular mechanisms driving this disease remain elusive. Here, we identify the multi-subunit ...
ORGANISM(S): Mus musculus 
2026-09-10 | GSE345497 | GEO
ProteomicsDiscovery of a small molecule inhibitor of the UBE2F-CRL5 axis that induces apoptosis and G2/M arrest and confers radiosensitization
Protein neddylation modification is catalyzed by a neddylation activating enzyme (NAE, E1), an E2 conjugating enzyme and an E3 ligase. In various types of human cancers, the neddylation pathway was abnormally activated. Our previous study validated that neddylation E2 UBE2F is a promising lung cance...
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD036191 | Pride
Ube2f  neddylation  apoptosis  cell cycle arrest  small molecule inhibitor 
UnknownThe E3 Ubiquitin Ligase CRL5 Regulates Dentate Gyrus Morphogenesis, Adult Neurogenesis, and Animal Behavior.
Not available
S-EPMC9253586 | biostudies-literature
TranscriptomicsCRL5-WSB2 Inactivation Drives BIM/NOXA-Mediated Neuronal Apoptosis in Luo-Agrawal Syndrome [hCOs]
Biallelic mutations in WSB2 have recently been linked to Luo-Agrawal syndrome, a newly recognized neurodevelopmental disorder characterized by severe microcephaly and brain hypoplasia; however, the precise molecular mechanisms driving this disease remain elusive. Here, we identify the multi-subunit ...
ORGANISM(S): Homo sapiens 
2026-09-10 | GSE345590 | GEO
UnknownA small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer.
Not available
S-EPMC9576757 | biostudies-literature
Sort   by:  
 Page size