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MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
UnknownCollaborative Research in Childhood Cancer Survivorship: The Current Landscape.
Not available
S-EPMC4567704 | biostudies-literature
MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
UnknownTransglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells.
Not available
S-EPMC2876729 | biostudies-literature
UnknownMinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome.
Not available
S-EPMC5793790 | biostudies-literature
ProteomicsQuantitative proteomics study of Mecp2 KO versus wild type mice
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. RTT is characterized by having apparently normal development until 6-18 months, when a progressive decline in motor and language functions begins and breathing abnormalities and...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-02 | PXD006460 | Pride
Dia Mouse brain cortex Rett syndrome 
MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
ProteomicsQuantitative Proteomic Analysis of an Alexander Disease Murine Model with Severe Reactive Gliosis
We performed label-free micro-data-independent acquisition (µDIA) to assay brain proteins from a severe model of Alexander disease (AxD, lethal at postnatal day ~35). Of the 5,005 proteins quantified, we observed upregulation of adipocytokine signaling, PPAR, insulin resistance, and glutathione pat...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-30 | PXD021884 | Pride
Reactive gliosis Alexander disease Parallel reaction monitoring Data-independent acquisition Brain proteome 
UnknownMinION Analysis and Reference Consortium: Phase 2 data release and analysis of R9.0 chemistry.
Not available
S-EPMC5538040 | biostudies-literature
ProteomicsInvestigation upon the state of p53 as well as interaction partners, in so much as can be learned from using the multi-component v5-dTag system.
Chromatin modifications provide additional context-dependence for DNA sequence-based gene regulation. Binding sites of the transcription factor (TF) and important tumour suppressor p53 are unusually diverse with regards to their chromatin accessibility and histone modifications, suggesting different...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD033674 | Pride
Trim24 Gene regulation Chromatin P53 
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