Sort   by:  
 Page size 
TranscriptomicsOptogenetic manipulation of BMP signalling to drive chondrogenic differentiation of hPSCs
Optogenetics is a rapidly advancing technology that combines photochemical, optical and synthetic biology techniques to control cellular behaviour and physiology. Combining sensitive light responsive optogenetic intervention tools with human pluripotent stem cell differentiation models has the poten...
ORGANISM(S): Homo sapiens 
2023-11-09 | E-MTAB-13377 | biostudies-arrayexpress
GenomicsOptogenetic neural stem cells microarray
Optogenetic neural stem cells microarray
PRJNA417074 | ENA
ProteomicsChronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer’s disease-like pathology
Neuronal overexcitability can disrupt synapse formation and strength and elicit synaptic changes which in turn give rise to neuronal hyperactivity, and eventually overall abnormal neural circuit processing. Such network disruption impairs neuronal function and survival, resulting in the onset of neu...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-01 | PXD044437 | Pride
Neuronal hyperactivity  hippocampus  optogenetics  stable step function opsin (ssfo)  proteomics  alzheimer’s disease  neurodegeneration 
UnknownOptogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation.
Not available
S-EPMC11364984 | biostudies-literature
ProteomicsDirected Differentiation of Human iPSCs into Mesenchymal Lineages by Optogenetic Control of TGF-β Signaling
For chondrogenic studies of optogenetically activated TGF-β signaling, optogenetic human iPSC-derived MSCs were encapsulated in hydrogels (20 million cells/mL of 2% agarose hydrogel). Groups received either no soluble TGF-β or optogenetic stimulation, or soluble TGF-β3 alone, or optogenetic stimulat...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040232 | Pride
Human Ipsc Chondrogenesis Hydrogel Agarose 
GenomicsOptogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome
Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome
PRJNA681840 | ENA
UnknownDisruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition.
Not available
S-EPMC7953993 | biostudies-literature
UnknownOptogenetic stimulation of the auditory pathway.
Not available
S-EPMC3934189 | biostudies-literature
UnknownSelective optogenetic stimulation of efferent fibers in the vagus nerve of a large mammal.
Not available
S-EPMC7836098 | biostudies-literature
TranscriptomicsRapid conversion of fibroblasts into functional forebrain GABAergic interneurons by direct genetic reprogramming
Transplantation of GABAergic interneurons (INs) can sustain long-standing benefits in animal models of epilepsy and other neurological disorders. In a therapeutic perspective, a renewable source of functional GABAergic INs is needed. Here, we identified five factors (Foxg1, Sox2, Ascl1, Dlx5 and Lhx...
ORGANISM(S): Mus musculus 
2015-12-15 | E-GEOD-74065 | biostudies-arrayexpress
Sort   by:  
 Page size