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ProteomicsUltra high resolution linear ion trap Orbitrap mass spectrometer (Orbitrap Elite) facilitates top down LC MS/MS and versatile peptide fragmentation modes
Although only a few years old, the combination of a linear ion trap with an Orbitrap analyzer has become one of the standard mass spectrometers to characterize proteins and proteomes. Here we describe a novel version of this instrument family, the Orbitrap Elite, which is improved in three main area...
ORGANISM(S): Homo sapiens (Human) 
2013-10-10 | PXD000508 | Pride
Cid High-field orbitrap analyzer Hcd Top down Shotgun proteomics 
Proteomicsα7 Nicotinic Acetylcholine Receptor-Associated Signaling in U87MG Glioblastoma Cells (LFQ, Orbitrap Elite)
This project investigates the role of α7 nicotinic acetylcholine receptor (α7 nAChR) signaling in glioblastoma using the U87MG human glioblastoma cell line. Cells were treated with selective α7 nAChR ligands (10 μM of agonist PNU282987, 1 μM of positive allosteric modulator PNU120596, 1 μM of antago...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD070911 | Pride
Glioblastoma  u87mg  α7 nicotinic acetylcholine receptor  choline  total proteome  label-free quantification  orbitrap elite  proteomics 
UnknownImmunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers.
Not available
S-EPMC3817719 | biostudies-literature
ProteomicsOptimizing chromatographic conditions for orbitrap-based MS platforms
We compared the performance of multidimensional protein identification (MudPIT) on Velos Pro Orbitrap (VPO) and Velos Orbitrap Elite (VOE) mass spectrometers to single dimension reversed phase (RP) chromatography on a Q Exactive Plus (QE+) and an Orbitrap Fusion™ Lumos™ (OFL). Using a digested HeLa...
ORGANISM(S): Homo sapiens (Human) 
2019-03-04 | PXD009875 | Pride
Reproducibility Data-dependent acquisition Chromatography Q exactive Fusion lumos Human Pearson product-moment correlation coefficient Distributed normalized spectral abundance factor Orbitrap Quantitative proteomics Multidimensional protein identification technology 
MetabolomicsOptimizing Deconvolution of Chimeric Fragmentation Spectra to reveal molecular structures of complex biological mixtures

Direct infusion mass spectrometry (DI-MS) offers a rapid, high-throughput analysis and, compared to liquid chromatography MS (LC-MS), a different analytical window into the composition of complex biological samples. However, the lack of chromatographic separation in DI-MS results in highly comple...

MTBLS13066 | MetaboLights
ProteomicsReprocessed: Chick utricle hair bundles and utricular epithelium—Orbitrap
This is a reanalysis of PXD000104. Purified hair bundles and utricular epithelium from E19-E20 chick inner ears were analyzed by LC-MS/MS to determine the abundant and enriched proteins of the hair bundle. This dataset used a Thermo Orbitrap Elite mass spectrometer for protein detection.
ORGANISM(S): Gallus gallus (Chicken) 
2015-11-17 | PXD002445 | Pride
Vestibular Hair cells Stereocilia Utricle 
UnknownEvaluating Chromatographic Approaches for the Quantitative Analysis of a Human Proteome on Orbitrap-Based Mass Spectrometry Systems.
Not available
S-EPMC6839767 | biostudies-literature
UnknownDDA-imaging with structural identification of lipid molecules on an Orbitrap Velos Pro mass spectrometer.
Not available
S-EPMC9541402 | biostudies-literature
ProteomicsGlycolytic modulation through HIF signaling determines HIV-1 elite control status
Natural control of HIV infection in Elite Controllers (EC) is a characteristic of <1% of HIV infected individuals. Extensive research has tried to elucidate the mechanism of control without any concrete results due to a large heterogeneity in the EC group, both between the sexes and how they obtain ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD023990 | Pride
Hiv-1 Elite controller Hif signaling Glycolysis 
ProteomicsglyXtoolMS Example Data Sets - glyXtoolMS: An Open-Source Pipeline for Semiautomated Analysis of Glycopeptide Mass Spectrometry Data
The data sets of human IgG and human fibrinogen are used as test data for the publication of glyXtoolMS (https://github.com/glyXera/glyXtoolMS). GlyXtoolMS is an open-source analysis software for the (semi)automated targeted analysis of glycopeptide mass spectrometry data using OpenMS/TOPPAS as a fr...
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD009716 | Pride
Glycosylation Glyxtoolms Human immunoglobulin gamma Ltq orbitrap elite Human fibrinogen 
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