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UnknownReal-Time Search-Assisted Acquisition on a Tribrid Mass Spectrometer Improves Coverage in Multiplexed Single-Cell Proteomics.
Not available
S-EPMC8961214 | biostudies-literature
ProteomicsReal-Time Search Assisted Acquisition on a Tribrid Mass Spectrometer Improves Coverage in Multiplexed Single-Cell Proteomics
In the young field of single-cell proteomics (scMS), there is a great need for improved global proteome characterization, both in terms of proteins quantified per cell and quantitative performance thereof. The recently introduced real-time search (RTS) on the Orbitrap Eclipse Tribrid mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD029320 | Pride
Human Orbitrap eclipse tribrid Single-cell proteomics 
ProteomicsTKO6: A Peptide Standard to Assess Interference for Unit-Resolved Isobaric Labeling Platforms
Protein abundance profiling using isobaric labeling is a well-established quantitative mass spectrometry technique. However, ratio distortion resulting from co-isolated and co-fragmented ions - commonly referred to as interference - remains a caveat of this technique. Tribrid mass spectrometers, suc...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-03-07 | PXD011653 | Pride
Tko  interference  tmt  itraq  sps-ms3 
UnknownTKO6: A Peptide Standard To Assess Interference for Unit-Resolved Isobaric Labeling Platforms.
Not available
S-EPMC6465125 | biostudies-literature
ProteomicsGlomerular filtrate proteins in acute cardiorenal syndrome
Acute cardiorenal syndrome (CRS-1) is a morbid complication of acute cardiovascular disease. Mechanistic investigations have focused on intrarenal cellular signaling induced by ischemia/reperfusion. Additional cardiorenal connector signals have been postulated, but investigation in CRS-1 has been li...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-27 | PXD012193 | Pride
Cardiovascular disease Urine Isobaric labeling Mouse model Acute cardiorenal syndrome Quantitative proteomics Tandem mass tags 
ProteomicsProtein composition of Toxoplasma endocytic and exocytic structures by proximity-dependent biotinylation
Toxoplasma gondii is a widely prevalent parasite of animals and humans that causes a broad spectrum of conditions ranging from asymptomatic or mild cold-like infections to abortion, severe ocular disease, encephalitis, and sometimes death. It is a member of the phylum Apicomplexa that also includes ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Toxoplasma gondii RH 
2023-04-17 | PXD034193 | Pride
K13 Sps-ms3 Bioid Endocytosis Membrane Inner membrane complex Exocytosis Toxoplasma gondii Tmt Apicomplexa Protist Apical annuli Protozoa Pellicle 
ProteomicsCharacterisation of proteome of a novel Escherichia coli strain exhibiting mucoviscous phenotype.
Protein expression by E. coli 26561 during the late-exponential phase of cultures under anaerobic conditions was examined. E. coli 26561 is a multidrug resistant (MDR) and shows an unusual hyper-mucoviscous phenotype. Resistance includes ESBL (CTX-M-14) and proteome was determined with and without...
ORGANISM(S): Escherichia coli 
2018-08-22 | PXD008339 | Pride
Anaerobic Ceftazidime Tmt Escherichia coli Antibiotic Mucoviscous Mic Shotgun Quantification 
ProteomicsRegulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway C4PR_LIV
The ATR-CHK1 signalling pathway responds to single strand DNA breaks and is required for cancer cells to survive the high levels of DNA replication stress and genomic instability resulting from the activity of oncogenes such as MYC. For this reason, inhibitors of CHK1 have great potential as anti-c...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-19 | PXD026203 | Pride
Sps-ms3 Mouse Tmt Phosphorylation Lc-ms/ms 
ProteomicsPseudomonas aeruginosa proteome under hypoxic stress conditions mimicking the cystic fibrosis lung
Pseudomonas aeruginosa is a Gram-negative, opportunistic bacterium and a major etiological agent in monogenic disease cystic fibrosis (CF). High density colonies of P. aeruginosa are often isolated from hypoxic mucus plugs in respiratory tract of CF patients, indicating high adaptive capacities of t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2017-08-29 | PXD007233 | Pride
Cystic fibrosis Hypoxia Pseudomonas aeruginosa Tmt-ms Swath-ms 
ProteomicsSystematic characterization of cancer-associated SPOP mutants reveals novel and reprogrammable degradative activities
Speckle-type POZ protein (SPOP) functions as the substrate adaptor of the Cullin3-RING ligase (CRL3) complex and is recurrently mutated in multiple cancer types. Among these, F102C and F133L are frequent prostate cancer mutations within the substrate-binding domain, yet their biochemical consequence...
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD071054 | Pride
E3 ligase Targeted protein degradation Proteomics 
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