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ProteomicssRNA scr5239 involved in important feedback loop of S. coelicolor central metabolism
The project is focused on the highly conserved sRNA scr5329 in Streptomyces coelicolor. A proteomics approach revealed that the sRNA regulates several metabolic enzymes, among them the Phosphoenolpyruvate-Carboxykinase (PEPCK), a key enzyme of the central carbon metabolism. The sRNA scr5239 promotes...
ORGANISM(S): Streptomyces coelicolor Bacteria 
2020-01-28 | PXD016811 | Pride
Carbon metabolism Srna Streptomyces Dasr 
ProteomicsMonoMac6 (MM6) cells proteomics LC-MS/MS
MicroRNAs (miRs) are small non-coding RNAs, which control the expression of target genes by either translational repression or RNA degradation, known as canonical miR function. MiR-328 has a non-canonical function and can activate gene expression by antagonizing the activity of heterogeneous ribonuc...
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD013106 | Pride
Inflammation Monomac6 (mm6) cells 
ProteomicsGlobal characterization of miR-574-5p decoy to CUGBP1 in human lung cancer using a mass spectrometry proteomics approach
We aimed to characterize decoy to the RNA-binding protein CUG-RNA binding protein 1 (CUGBP1 mechanism in A549 lung cancer cells. We identified several new canonical targets of CUGBP1 but those were not regulated by miR-574-5p via the decoy mechanism. This can be explained by the localization of CUG...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016803 | Pride
Cugbp1 Mir-574-5p Human Lung cancer Mpges-1 
ProteomicsInhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
We compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1β induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE2 production and increased PGF2α and throm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD013490 | Pride
Inflammation A549 Cancer Mpges-1 Lc-ms/ms 
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