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ProteomicsOxidative posttranslational modifications of cysteine are associated to high intrinsic aerobic capacity in the skeletal and cardiac muscle
Oxidative posttranslational modifications (Ox-PTMs) regulate cellular homeostasis in several tissues, including skeletal and cardiac muscles. The putative relationship between Ox-PTMs and intrinsic components of oxidative energy metabolism has not been previously described. We determined the metabol...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD009109 | Pride
Heart Ox-ptm Mdh1 Redox proteomics Exercise Icat Mitochondria Cysteine Cardiac Aerobic Skeleta Oxidation Oxidative stress Posttranslational modifications Muscle 
ProteomicsIdentification of oxidized cysteine residues in signaling proteins in U937 cells at basal levels and upon diamide and hypochlorous acid stimulations.
Here, we report a detection of oxidative post-translational modifications (ox-PTM) of Cys residues in the U937 cell line either non-stimulated or stimulated with diamide, a thiol-oxidizing agent at 0.5mM for 20min or HOCl at 100µM for 10min. Reversible Cys ox-PTMs were labelled using a bioswitch met...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD020270 | Pride
Post-translational modifications Mass spectrometry Oxidation Cysteine Redox Signaling 
UnknownRedox regulation of mitochondrial ATP synthase: implications for cardiac resynchronization therapy.
Not available
S-EPMC3500591 | biostudies-literature
UnknownDifferential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity.
Not available
S-EPMC6289973 | biostudies-literature
UnknownGenetic Code Expansion: A Powerful Tool for Understanding the Physiological Consequences of Oxidative Stress Protein Modifications.
Not available
S-EPMC5937447 | biostudies-literature
UnknownRedox proteomics and structural analyses provide insightful implications for additional non-catalytic thiol-disulfide motifs in PDIs.
Not available
S-EPMC9868663 | biostudies-literature
UnknownThe protease activity of human ATG4B is regulated by reversible oxidative modification.
Not available
S-EPMC8386634 | biostudies-literature
ProteomicsDNMT3L safeguards the epigenome and developmental potential of naive human pluripotent stem cells and blastoids
Studies of the catalytically inactive DNA methyltransferase Dnmt3l have mainly been limited to mice where Dnmt3l was shown to be essential for fertility, de novo DNA methylation in early embryos and maintenance of DNA methylation patterns in mouse pluripotent stem cells. In humans, recent work revea...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD053638 | Pride
Dnmt3l  naive pscs  blastoids  histones  ptms  protein interactions 
ProteomicsFilling the Gaps in Peptide Maps with a Platform Assay for Top-Down Characterization of Purified Protein Samples
LC-MS intact mass analysis and LC-MS/MS peptide mapping are foundational assays for developing biologic drugs and other commercial protein products. Certain PTM types, such as truncation and oxidation, increase the difficulty of precise proteoform characterization owing to inherent limitations in pe...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2024-06-12 | MSV000095009 | MassIVE
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