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ProteomicsOxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
Protein glycosylation, a complex and heterogeneous post-translational modification that is frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a data-independent acquisition technique for the large-scale mass-spectrometric quantification of glycopeptides in pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-29 | MSV000089567 | MassIVE
ProteomicsOxonium ion guided analysis of quantitative proteomics data reveals site-specific O-glycosylation of anterior gradient protein 2 (AGR2)
Developments in mass spectrometry (MS)-based analyses of glycoproteins have been important to study changes in glycosylation related to disease. Recently, the characteristic pattern of oxonium ions in glycopeptide fragmentation spectra had been used to assign different sets of glycopeptides. In part...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025805 | Pride
Glycoproteomics  tmt labeling  oxonium ion  lc−ms/ms  o-glycosylation  colorectal cancer  agr2 
ProteomicsOxonium Ion-Guided Ion Mobility-Assisted Glycoproteomics on the timsTOF Pro
Spatial separation of ions in the gas-phase, providing information about their size as collisional cross-sections, can readily be achieved through ion mobility. The timsTOF Pro combines a trapped ion mobility device with a quadrupole, collision cell and a time-of-flight analyser to enable the analys...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD034845 | Pride
Tims N-glycopeptides Oxonium ions Plasma Neutrophils Ion mobility 
UnknownControl of stereogenic oxygen in a helically chiral oxonium ion.
Not available
S-EPMC10017494 | biostudies-literature
UnknownOn Silylated Oxonium and Sulfonium Ions and Their Interaction with Weakly Coordinating Borate Anions.
Not available
S-EPMC7028070 | biostudies-literature
UnknownOxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics.
Not available
S-EPMC10963274 | biostudies-literature
UnknownData-independent oxonium ion profiling of multi-glycosylated biotherapeutics.
Not available
S-EPMC6204843 | biostudies-literature
UnknownOxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2).
Not available
S-EPMC8160981 | biostudies-literature
UnknownAnnulations of enantioenriched allenylsilanes with in situ generated iminium ions: stereoselective synthesis of diverse heterocycles.
Not available
S-EPMC3164280 | biostudies-literature
ProteomicsUnderstanding m/z range settings for MS/MS scans: a case study with intact glycopeptides
Several practical considerations dictate the scan range, or breadth of ion m/z values, that can be transmitted through ion guides in mass spectrometers (MS). Voltage settings must be balanced to minimize low m/z cutoffs while also generating effective pseudopotential wells for high m/z ions to maxim...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD062360 | Pride
Glycobiology Glycopeptides Mass spectrometry Mass range 
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