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ProteomicsThermal proteome profiling reveals distinct target selectivity for differentially oxidized oxysterols
The dataset contains mass spectrometric raw data from Thermal Proteomic Profiling experiments aimed to identify the protein targets of three A- and B-ring oxidized sterols (cholestane-3beta,5alfa,6beta-triol (CT), 7keto-cholesterol (7-KC), 4beta-hydroxycholesterol (4beta-HC) ) and a side-chain oxidi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-16 | MSV000089661 | MassIVE
ProteomicsAnalysis of mixed-oxysterol treatment on the THP-1 macrophage
THP-1 monocytes were differentiated, via PMA treatment, to macrophages. THP-1 macrophages were then treated with a mixed-oxysterol treatment (7-ketocholesterol and 7beta-hydroxycholesterol) for 24 hours. The mixed-oxysterol treatment was mixed to a ratio that represents the cytotoxic oxysterol conte...
ORGANISM(S): Homo sapiens (Human) 
2017-03-15 | PXD004304 | Pride
Thp-1 Macrophage Proteomics Oxysterol 2-de Tandem-mass spectrometry 
TranscriptomicsExpression of oxysterol pathway genes in estrogen positive breast carcinomas-second phase
Metabolism of anticancer drugs markedly affects their antitumor effects. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing taxanes and/or anthracyclines with therapy response and survival of breast carcinoma patients The present study investigated...
ORGANISM(S): Homo sapiens 
2017-04-06 | GSE85206 | GEO
TranscriptomicsExpression of oxysterol pathway genes in estrogen positive breast carcinomas-first phase
Metabolism of anticancer drugs markedly affects their antitumor effects. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing taxanes and/or anthracyclines with therapy response and survival of breast carcinoma patients The present study investigated...
ORGANISM(S): Homo sapiens 
2017-04-06 | GSE85207 | GEO
Genomics
Genetic background of oxysterol-related genes in breast cancer
PRJNA802324 | ENA
GenomicsAutism-relevant oxysterol signaling regulates GABAergic neurogenesis and interneuron subtype specification
Autism-relevant oxysterol signaling regulates GABAergic neurogenesis and interneuron subtype specification
PRJNA1270040 | ENA
TranscriptomicsArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
RELEVANCE: Smith-Lemli-Opitz syndrome (SLOS) is a human disease caused by mutations in the gene coding for the enzyme DHCR7 (7-dehydrocholesterol (7DHC) reductase), which catalyzes the final step of cholesterol biosynthesis. Accumulated 7DHC in tissues and body fluids of SLOS patients gives rise t...
ORGANISM(S): Mus musculus 
2021-03-20 | E-MTAB-10055 | biostudies-arrayexpress
UnknownOxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Not available
S-EPMC3749252 | biostudies-literature
UnknownThe Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice.
Not available
S-EPMC3941159 | biostudies-literature
UnknownOxysterol research: a brief review.
Not available
S-EPMC6490702 | biostudies-literature
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