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ProteomicsThe proteome of normal human retina
The retina is a delicate tissue that detects light, converts photochemical energy into neural signals, and transmits the signals to the visual cortex of the brain. A detailed protein inventory of the proteome of the normal human eye may provide a foundation for new investigations into both the physi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-26 | MSV000079537 | MassIVE
TranscriptomicsStaphylococcus aureus REX mutant
The transcription level of a rex-deficient S. aureus mutant in comparison to its parental strain S. aureus SH1000 was analyzed using DNA microarrays. S. aureus N315 microarrays were purchased from Scienion (Scienion AG, Berlin, Germany) and were produced by spotting 2,338 PCR products of the 2,593 O...
ORGANISM(S): Staphylococcus aureus 
2010-05-16 | E-GEOD-17128 | biostudies-arrayexpress
ProteomicsBALF exosomes - Pulmonary Sarcoidosis is Associated With Exosomal Vitamin D-Binding Protein and Inflammatory Molecules
Using 8-plex iTRAQ labelling exosmes isolated from bronchial lavage (BALF) were analyzed by LC-MS/MS. The measurements compared control subjects with sarcoidosis patients (15 in all) ; five with löfgrens syndrome and 10 with regular sacroidosis
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD001808 | Pride
Sarcoidosis Exosome Balf 
ProteomicsProtein composition of extracellular vesicles isolated from Haloferax volcanii
In order to understand extraceluular vesicle (EV) production in Euryarchaea, and in particular halophilic archaea, we used the model archaeal organism, Haloferax volcanii, to investigate the composition of EVs as well as their capacity to transfer their cargo to other organisms. EVs were isolated in...
ORGANISM(S): Haloferax volcanii DS2 
2024-05-24 | PXD038319 | Pride
Haloarchaea Extracellular vesicles 
ProteomicsComprehensive redox profiling of the thiol proteome of Clostridium difficile
The strictly anaerobic bacterium C. difficile has become one of the most problematic hospital acquired pathogens and a major burden for health care systems. Although antibiotics work effectively in most C. difficile infections (CDIs), their detrimental effect on the intestinal microbiome paves the w...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2018-03-05 | PXD007278 | Pride
Thiol redox proteomics Clostridium difficile 
ProteomicsA plasmid goes viral, part 2 - A plasmid from an Antarctic haloarchaeon uses specialized membrane vesicles to disseminate and infect plasmid-free cells
Analysis of protein compostition of plasmid vesicles (PVs) purified through CsCl gradients.
ORGANISM(S): Halorubrum lacusprofundi ATCC 49239 
2017-07-14 | PXD006515 | Pride
Membrane vesicles Virus Haloarchaea Plasmid 
ProteomicsIn-Gel digest and filter-aided sample preparation to identify Dermatophagoides - and yeast protein antigens in severe equine asthma.
Severe equine asthma (SEA) is a common, chronic respiratory disease of horses characterized by hyperreactivity to hay dust which has many similarities to severe neutrophilic asthma in humans. A 2D immunoblot approach was used to identify quantitative differences in the recognition of the two-dimensi...
ORGANISM(S): Dermatophagoides Pteronyssinus Saccharomyces Cerevisiae 
2024-01-26 | PXD045568 | panorama
TranscriptomicsA positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B mono-ubiquitylation to regulate transcript elongation in fission yeast
Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification within transcribed regions, but it remains uncertain how these modifications influence, or are influenced by, properties of the elongation complex. Here we establish an intimate link betw...
ORGANISM(S): Schizosaccharomyces pombe 
2012-12-01 | E-GEOD-31070 | biostudies-arrayexpress
ProteomicsIdentification of a Ste20-like kinase-dependent network orchestrating cytoskeletal and synaptic development of cortical neurons. Untargeted phosphorylation analysis
The Ste20-like kinase (Slk) is a serine/threonine kinase that regulates cytoskeletal organization, apoptosis, and cell polarity in non-neuronal cells. In neurons, Slk guides dendrite morphogenesis and inhibitory synapse stability, controlling excitation-inhibition balance through parvalbumin interne...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-10-02 | PXD073661 | Pride
Germinal center kinases Kinase signaling Affinity purification-mass spectrometry Lc/ms Protein-protein interactions Phosphoproteomics 
UnknownAssociation of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Not available
S-EPMC3077716 | biostudies-literature
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