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ProteomicsFucosylation of HLA-DRB1 regulates CD4+T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy: CD4+ T Cell Phosphoproteomics
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment. In addition to ineffective patient stratification, efficacy is impaired by paucity of intratumoral immu...
ORGANISM(S): Homo sapiens (Human) 
2022-12-16 | PXD038065 | Pride
Phosphoproteomics Fucosylation Melanoma Cd4 t cells Immunotherapy 
ProteomicsBreast cancer stem cell-derived tumors escape from γδ T cell immunosurveillance in vivo by modulating γδ T cell ligands
Triple negative breast cancer (TNBC) lacks targeted therapy options. TNBC is enriched in breast cancer stem cells (BCSCs), which play a key role in metastasis, chemoresistance, relapse and mortality. γδ T cells hold great potential in immunotherapy against cancer, and might be an alternative to targ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD039463 | Pride
Breast cancer stem cells Proteomics Tmt Immune-escape Lc-ms Quantitation Immunotherapy Γδ t cells Phosphoantigens Triple negative breast cancer 
UnknownBlocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma
Not available
S-SCDT-10_15252-EMMM_202115200 | biostudies-other
UnknownHuman In vitro Modeling Identifies Adjuvant Combinations that Unlock Antigen Cross-presentation and Promote T-helper 1 Development in Newborns, Adults and Elders.
Not available
S-EPMC10922990 | biostudies-literature
UnknownM. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1.
Not available
S-EPMC5960073 | biostudies-literature
UnknownEndophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.
Not available
S-EPMC6538628 | biostudies-literature
TranscriptomicsDexamethasone treatment of gut cells
Reference pool RNA versus RNA from dexamethasone treated gut cells.
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-1826 | biostudies-arrayexpress
TranscriptomicsRNA-seq in GR18 cell line to identify genes regulated by the Glucocorticoid Receptor
To identify the genes regulated by the Glucocorticoid Receptor (GR), we performed RNA-seq in GR18 cell line (derived from U2OS ATTC:HTB-96, stably transfected with an expression construct for GR), upon glucocorticoid (dexamethasone) or vehicle (ethanol) treatment.
ORGANISM(S): Homo sapiens 
2018-10-29 | E-MTAB-6738 | biostudies-arrayexpress
ProteomicsMetaprotemic analysis of groundwaters from a coal tar-contaminated aquifer in South Glens Falls, NY: MW37, Shotgun 2
Deciphering the in situ activities of microorganisms is essential for understanding the biogeochemical processes occurring in complex environments. Here we used environmental metaproteomics to obtain information about the identity and activity of subsurface microbial populations in coal-tar-contamin...
ORGANISM(S): prokaryotic environmental samples 
2022-02-22 | PXD001037 | Pride
In-situ gene expression  microbial ecology  metaproteomics  candidatus methylomirabilis oxyfera 
ProteomicsMetaprotemic analysis of groundwaters from a coal tar-contaminated aquifer in South Glens Falls, NY: MW37, Shotgun 1
Deciphering the in situ activities of microorganisms is essential for understanding the biogeochemical processes occurring in complex environments. Here we used environmental metaproteomics to obtain information about the identity and activity of subsurface microbial populations in coal-tar-contamin...
ORGANISM(S): prokaryotic environmental samples 
2022-02-22 | PXD001036 | Pride
In-situ gene expression  microbial ecology  metaproteomics  candidatus methylomirabilis oxyfera 
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