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ProteomicsBlocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway
Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies.
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058262 |
ProteomicsComparative cell surface proteomic analysis of the primary human T cell and monocyte responses to type I interferon
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the initial portal of entry for viruses. Nonetheless, the effect of IFN on PM ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD022834 | Pride
T cell Leukocytes Cell surface Antiviral restriction Monocyte Quantitative proteomics Interferon type i (ifn) Plasma membrane 
MetabolomicsPolymicrobial detection and metabolomics in saliva of children with early childhood caries

Cariogenic microorganisms as well as salivary metabolic status in early childhood caries (ECC) have been reported to differ from that in adult caries. The main aim of this study was to identify specific microbial species and salivary metabolites in children with ECC using species-specific qPCR an...

2024-11-12 | MTBLS10890 | MetaboLights
ProteomicsSugarQuant: a streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics
Site-specific regulation of protein N-glycosylation is essential in human cells. However, accurate quantification of glycosylation sites and their individual glycan moieties in a cell-wide manner is still technically challenging. Here, we introduce SugarQuant, an integrated mass spectrometry-based p...
ORGANISM(S): Homo sapiens (Human) 
2020-08-24 | PXD018349 | Pride
Glycosylation 
UnknownEffect of Chang'an decoction on ulcerative colitis by regulating T helper 17 cells and regulatory T cellsRab27 in the p53/high mobility group box 1 pathway.
Not available
S-EPMC12453985 | biostudies-literature
UnknownEmergence of T cell immunosenescence in diabetic chronic kidney disease.
Not available
S-EPMC7574244 | biostudies-literature
ProteomicsThe pan-cancer lncRNA PLANE regulates an alternative splicing program and promotes cancer pathogenesis
Proteome analysis of Biotin- PLANE pull-down assays
ORGANISM(S): Homo Sapiens 
2020-11-26 | PXD022747 |
TranscriptomicsTranscription profiling of mouse dendritic cells from wild type, CIITA-/- and I-A beta -/- strains representing CIITA-deficient, MHC class II-deficient and control mice
Triplicates preparations of RNA from day 10 DC's. Experiment is described in Wong et al 2003 Nat. Immunol.
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-557 | biostudies-arrayexpress
ProteomicsAnti-Toxoplasma gondii effect of vorinostat in vitro and in vivo
Toxoplasma gondii is an important pathogenic protozoon that infects up to one-third of the world's population. In immunocompetent individuals, the infection generally is asymptomatic. However, in immunocompromised patients, the infection can lead to severe and fatal complications. This is due to the...
ORGANISM(S): Toxoplasma Gondii Rh-88 
PXD053997 |
ProteomicsBiotin-13-cis retinoic acid pulldown LC-MSMS
We performed pulldown assays followed by mass-spectrometry analysis using biotin-tagged 13-cis retinoic acid to identify its binding targets in HeLa cells
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD029579 | Pride
Human Biotin-13-cis retinoic acid lc-msms 
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