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ProteomicsParalog protein compensation preserves protein-protein interaction networks following gene loss cancer
Abstract Proteins operate within dense interconnected networks, where interactions are necessary both for stabilising proteins and enabling them to execute their molecular functions. Remarkably, the protein-protein interaction networks operating within tumour cells continue to function despite wide...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055643 | Pride
Protein-protein interaction Compensation Paralog protein Cancer. 
ProteomicsRibosome heterogeneity in Drosophila melanogaster gonads through paralog-switching
Ribosomes have long been thought of as homogeneous macromolecular machines, but recent evidence suggests they are heterogeneous and could be specialised to regulate translation. Here, we have isolated ribosomal complexes and characterised their protein content across 4 tissues of Drosophila melanoga...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-07-22 | PXD026227 | Pride
Gonads Testis Tmt-ms Ribosome Paralog Drosophila melanogaster Ovary 
ProteomicsConserved exchange of paralog proteins during neuronal differentiation
Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-07 | PXD027387 | Pride
Development Protein complex Transport Paralog Proteome Neuronal differentiation 
GenomicsSTAT5 paralog dose governs T cell effector and regulatory function
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remains controversial. We addressed this longstanding question in primary CD4+ 'helper' T cells...
ORGANISM(S): Mus musculus 
2016-03-28 | E-GEOD-77656 | biostudies-arrayexpress
TranscriptomicsNrf2b: a novel zebrafish paralog of the oxidant-responsive transcription factor Nrf2.
We identified a novel paralog of the antioxidant response element transcription factor, Nrf2 in zebrafish. To determine whether the paralogs Nrf2a and Nrf2b regulate different sets of genes, we performed loss-of-function experiments followed by microarray-based gene expression profiling, performed ...
ORGANISM(S): Danio rerio 
2011-12-20 | E-GEOD-32594 | biostudies-arrayexpress
GenomicsPolycomb Protein Ezh1 Promotes RNA Polymerase II Elongation
Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, Enhancer of Zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine-27 of histone H3 (...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-25549 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae ribosomal protein knockouts
Duplicated genes escape gene loss by conferring a dosage benefit or evolving diverged functions. The yeast Saccharomyces cerevisiae contains many duplicated genes encoding ribosomal proteins. Prior studies have suggested that these duplicated proteins are functionally redundant and affect cellular...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-8761 | biostudies-arrayexpress
ProteomicsConserved exchange of paralog proteins during neuronal differentiation
Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-03-07 | PXD027191 | Pride
Neuronal differentiation Protein complexes Paralogs 
ProteomicsConserved exchange of paralog proteins during neuronal differentiation
Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-07 | PXD027195 | Pride
Neuronal differentiation Protein complexes Mouse Paralogs 
GenomicsDiscovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies
Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies
PRJNA1284952 | ENA
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