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TranscriptomicsThe direction of cross affects obesity after puberty in male but not female offspring
We investigated parent-of-origin and allele-specific expression effects on obesity and hepatic gene expression in reciprocal crosses between the Berlin Fat Mouse Inbred line (BFMI) and C57Bl/6NCrl (B6N). We sequenced mRNA extracted from liver tissue of 10 M. Musculus individuals. 4 liver samples wer...
ORGANISM(S): Mus musculus 
2015-11-11 | E-GEOD-74889 | biostudies-arrayexpress
ProteomicsThe Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR are Based on Highly Similar Proteome and Degradome Alterations
ADAM17 and EGFR are essential key players for epidermal integrity. Keratinocyte-specific deletion of ADAM17 in mice results in pronounced alterations in terminal differentiation of keratinocytes leading to severe epidermal barrier defects with enhanced transepidermal water loss. Thereby, mice defici...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-20 | PXD002597 | Pride
Proteomics Skin Degradomics 
UnknownThe Effect of Scandium on the Structure, Microstructure and Superconductivity of Equimolar Sc-Hf-Nb-Ta-Ti-Zr Refractory High-Entropy Alloys.
Not available
S-EPMC8838456 | biostudies-literature
ProteomicsProteomic analyses identified distinct types of vesicles essential for egress of Plasmodium falciparum gametocytes from red blood cells
Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the gametocytes. Upon entering the mosquito midgut, the gametocytes egress from the enveloping erythrocyte while passing through gametogenesis. Egress follows an inside-out mode during which the membrane of the ...
ORGANISM(S): Plasmodium Falciparum 
2024-01-25 | PXD039679 | JPOST Repository
TranscriptomicsFine mapping of genome activation in bovine embryos by RNA sequencing
During maternal-to-embryonic transition control of embryonic development gradually switches from maternal RNAs and proteins stored in the oocyte to gene products generated after embryonic genome activation (EGA). Detailed insight into the onset of embryonic transcription is obscured by the presence ...
ORGANISM(S): Bos taurus 
2014-02-09 | E-GEOD-52415 | biostudies-arrayexpress
TranscriptomicsmiR-31 inhibits lymphatic lineage-specific differentiation in vitro and lymphatic vessel development in vivo
The lymphatic vascular system maintains tissue fluid homeostasis, helps mediate afferent immune responses and promotes cancer metastasis. MicroRNAs (miRNAs) have recently emerged as key and potent regulators of the genome that control virtually all aspects of cell and organism biology. Surprisingly,...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-16908 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of nine European maize (Zea mays L.) inbred lines and nine corresponding hybrids
In this study expression levels of 732 genes were analyzed for European maize (Zea mays L.) inbred lines (4 Flint and 5 Dent) and nine corresponding hybrids by microarray analysis. The selection of the 732 genes was based on a previous study (Thiemann et al., Theor Appl Genet 2010, 120:401-413), whi...
ORGANISM(S): Zea mays 
2014-04-03 | E-GEOD-52411 | biostudies-arrayexpress
UnknownAffinity of fentanyl and its derivatives for the σ1-receptor.
Not available
S-EPMC6657672 | biostudies-literature
ProteomicsA general workflow for E3 ligase ligand validation for PROTAC development
PROteolysis TArgeting Chimeras (PROTACs) have gained considerable attention as a new modality in drug discovery. However, the development of PROTACs has been mainly focused on CRBN (Cereblon) and VHL (van Hippel-Lindau Ligase) ligands. The considerable size of the human E3 ligase family, newly devel...
ORGANISM(S): Homo sapiens (Human) 
2025-04-04 | PXD057431 | Pride
Protac Vhl Promiscious kinase inhibitor 
UnknownPolygenic analysis and targeted improvement of the complex trait of high acetic acid tolerance in the yeast Saccharomyces cerevisiae.
Not available
S-EPMC4702306 | biostudies-literature
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