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UnknownThe Association between Low Muscle Mass and Hepatic Steatosis in Asymptomatic Population in Korea.
An association between low muscle mass and nonalcoholic fatty liver disease (NAFLD) has been suggested. We investigated this relationship using controlled attenuation parameter (CAP). A retrospective cohort of subjects had liver FibroScan® (Echosens, Paris, France) and bioelectrical impedance analys...
S-EPMC8400877 | biostudies-literature
ProteomicsPeptidylarginine deiminase 2 (PADI2) is a key regulator for osteoblast differentiation and bone formation through the maintenance of citrullination-mediated RUNX2 stability
Peptidylarginine deiminase (PADI) 2 catalyzes the posttranslational conversion of peptidyl-arginine to peptidyl-citrulline, a process called citrullination. However, the exact function of PADI2 in bone development and bone homeostasis remains unknown. In this study, we found that Padi2 deficiency le...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040179 | Pride
Citrullination Ptm Padi2 Lc-msms Runx2 
UnknownChronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus.
Recent evidence indicates that ultraviolet (UV) exposure of the skin can affect brain functions such as learning and memory, addictive behavior, and hippocampal neurogenesis. These changes are closely associated with hippocampal function, which plays a pivotal role in learning and memory formation. ...
S-EPMC9768969 | biostudies-literature
UnknownA novel continuous hydrodynamic cavitation technology for the inactivation of pathogens in milk.
Hydrodynamic cavitation is a powerful tool for the enhancement of various processing applications. This study utilizes continuous hydrodynamic cavitation (CHC) for the inactivation of pathogens in milk for the first time. The thermal characteristics, inactivation performance, damage on the nutrition...
S-EPMC7786570 | biostudies-literature
UnknownNuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.
Aberrant expression of casein kinase 2 (CK2) is associated with tumor progression; however, the molecular mechanism by which CK2 modulates tumorigenesis is incompletely understood. In this paper, we show that CK2α phosphorylates the C-terminal domain of the nuclear receptor corepressor (NCoR) at Ser...
S-EPMC3408420 | biostudies-literature
UnknownxCITED2 Induces Neural Genes in Animal Cap Explants of Xenopus Embryos.
Neural tissue is arisen from presumptive ectoderm via inhibition of bone morphogenetic protein (BMP) signaling during Xenopus early development. Previous studies demonstrate that ectopic expression of dominant negative BMP4 receptor (DNBR) produces neural tissue in animal cap explants (AC) and also ...
S-EPMC3214773 | biostudies-literature
UnknownDevelopment and Validation of an Enzyme-Linked Immunosorbent Assay-Based Protocol for Evaluation of Respiratory Syncytial Virus Vaccines.
Recently, respiratory syncytial virus (RSV) vaccines based on the prefusion F (pre-F) antigen were approved in the United States. We aimed to develop an enzyme-linked immunosorbent assay (ELISA)-based protocol for the practical and large-scale evaluation of RSV vaccines. Two modified pre-F proteins ...
S-EPMC11209066 | biostudies-literature
UnknownPeptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination.
Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-arginine to peptidyl-citrulline in a process called citrullination. However, the precise functions of PADI2 in bone formation and homeostasis remain unknown. In this study, our objective was to elucidate the ...
S-EPMC10468518 | biostudies-literature
UnknownTargeted next-generation sequencing at copy-number breakpoints for personalized analysis of rearranged ends in solid tumors.

Background

The concept of the utilization of rearranged ends for development of personalized biomarkers has attracted much attention owing to its clinical applicability. Although targeted next-generation sequencing (NGS) for recurrent rearrangements has been successful in hematologic maligna...
S-EPMC4061055 | biostudies-literature
UnknownThe integrity of thalamo-dorsolateral prefrontal cortex tract: a key factor in residual consciousness in disorders of consciousness patients.

Background

The mesocircuit model describes a complex network that includes the prefrontal cortical-striatopallidal-thalamo-cortical loop systems and is involved in the mechanism underlying consciousness in patients with disorders of consciousness (DoC). Inhibitory signals to the thalamus bec...
S-EPMC11349516 | biostudies-literature
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