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ProteomicsProteomic analysis of L6 myoblasts treated with C-terminal transgelin peptides
To investigate bioactivity of peptides identified in human plasma, we treated L6 myoblasts in vitro with a synthetic C-terminal peptide from TAGLN spanning amino acids 179-200, or a synthetic C-terminal peptide from TAGLN2 spanning amino acids 178-199 (1 µg/mL; 7 days), and compared the treatments t...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-11-21 | PXD007176 | Pride
Peptidomics Myoblasts Proteomics 
TranscriptomicsGrowth phase-dependent activation of the DccRS regulon of Campylobacter jejuni
Two-component systems are widespread prokaryotic signal transduction devices which allow the regulation of cellular functions in response to changing environmental conditions. The two-component system DccRS (Cj1223-Cj1222) of Campylobacter jejuni is important for the colonization of chickens. Here w...
ORGANISM(S): Campylobacter jejuni subsp. jejuni 81116 
2010-01-09 | E-GEOD-19803 | biostudies-arrayexpress
ProteomicsPhosphoproteomics of cardiac organoids derived from ALPK3 knockout hPSCs
Pathogenic mutations in alpha kinase 3 (ALPK3) cause cardiomyopathy and a range of musculoskeletal defects. How ALPK3 mutations result in disease remains unclear and little is known about this atypical kinase. Using a suite of engineered human pluripotent stem cells (hPSCs) we show that ALPK3 locali...
ORGANISM(S): Homo sapiens (Human) 
2023-01-19 | PXD035535 | Pride
Cardiac organoids Alpk3 Phosphoproteomics 
ProteomicsAP-MS of ALPK3 in cardiomyocytes
Pathogenic mutations in alpha kinase 3 (ALPK3) cause cardiomyopathy and a range of musculoskeletal defects. How ALPK3 mutations result in disease remains unclear and little is known about this atypical kinase. Using a suite of engineered human pluripotent stem cells (hPSCs) we show that ALPK3 locali...
ORGANISM(S): Homo sapiens (Human) 
2023-01-19 | PXD035734 | Pride
Interactome Alpk3 
ProteomicsASB2beta-induced changes to the skeletal muscle proteome and ubiquitinome
Ubiquitination is a post-translational modification that has been shown to have a range of effects, such as regulating protein function, protein:protein interactions, protein localization, and protein abundance by targeting proteins for degradation by the 26S proteasome. We have previously shown th...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-18 | PXD020040 | Pride
Adeno-associated virus Skeletal muscle Ubiquitin 
ProteomicsProteomics analysis of regulation by Bmal1 and physiological time-restricted feeding
To define regulation of tissue proteomes by Bmal1, daily feeding rhythm, and the interaction, we employed Bmal1-stopFL mice, which do not express the main transcriptional activator of the molecular clock, Bmal1, except in cre recombinase-expressing cells1,2 (Figure 1A). Bmal1-stopFL mice lacking cre...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD040362 | Pride
Circadian rhythm Liver Bmal1 Clock Muscle 
ProteomicsASB2 interactome in C2C12 cells
Ubiquitination is a post-translational protein modification that has been shown to have a range of effects, including regulation of protein function, interaction, localization, and degradation. We have previously shown that the muscle-specific ubiquitin E3 ligase, ASB2β, is down-regulated in models...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-18 | PXD023391 | Pride
Protein interactions Asb2 E3 ligase 
ProteomicsProteomic analysis of NFIX over-expression in C2C12 myotubes
Overexpressed either GFP, wild-type (WT) NFIX or a phospho-dead mutant of NFIX in which eight serine residues surrounding S286 were mutated to alanine (S265/267/268/271/272/273/274/275A) was performed C2C12 cells prior to the induction of myogenesis. Cells were harvest 2 days post induction of myoge...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-18 | PXD028718 | Pride
Nfix C2c12 Myoblasts Myotubes 
ProteomicsIdentification of neoantigens in oesophageal adenocarcinoma
We present data from tissues of seven oesophageal adenocarcinomas of CD4 and CD8 T cell epitopes eluted from the cell surface using mass spectrometry (immunopeptidomics) of presented HLA bound peptides.This dataset forms part of the publication:Nicholas, B., Bailey, A., McCann, K.J., Wood, O., Walke...
ORGANISM(S): Homo sapiens (Human) 
2022-09-27 | PXD031108 | Pride
Human Oesophageal adenocarcinoma Immunopeptidome Hla 
ProteomicsProteomic analysis of NDUFS4 KO hearts
we performed whole heart proteomic analyses in both WT and NDUFS4 heart-specific cKO mice (n = 5 mice/group).
ORGANISM(S): Mus musculus (Mouse) 
2023-06-01 | PXD036399 | Pride
Ndufs4 
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