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ProteomicsAblation of mitochondrial rhomboid Parl causes Leigh syndrome
The mitochondrial intramembrane rhomboid protease Parl plays essential roles in cell death but its physiological contribution remains unclear. In the present study we show that Parl ablation causes a dramatic necrotic neurodegeneration consistent with Leigh syndrome, a mitochondrial disease characte...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-21 | PXD008908 | Pride
Leigh syndrome Pgam5 Rhomboids Proteolysis Necrosis Ttc19 Complex iii Apoptosis Neurodegeneration Parl Pink1 
ProteomicsHELA cells PARL Immunoprecipitation
The SPFH (Stomatin, Prohibitin, Flotillin, HflC/K) superfamily is composed of scaffold proteins that form ring-like structures and locally specify the protein-lipid composition in a variety of cellular membranes. Stomatin-like protein 2 (SLP2) is a member of this superfamily that localizes to the...
ORGANISM(S): Homo sapiens (Human) 
2016-10-18 | PXD004914 | Pride
Hela Parl Flag-ip 
ProteomicsHELA cells PARL Immunoprecipitation part II
Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid-like protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and cell death pathways, but its role in apoptosis remained enigmatic. Here...
ORGANISM(S): Homo sapiens (Human) 
2017-03-01 | PXD005712 | Pride
Human S277a parl mutant 
ProteomicsThe rhomboid protease PARL regulates apoptosis via proteolytic maturation of Smac/DIABLO in mitochondria
Substrates of the mitochondrial protease PARL were identified using quantitative N-terminal ChaFRADIC:
ORGANISM(S): Homo sapiens (Human) 
2017-03-09 | PXD005535 | Pride
Parl substrates Chafradic N-terminomics 
UnknownStructural and mechanistic basis of Parl activity and regulation.
Not available
S-EPMC3134571 | biostudies-literature
UnknownGenetic variation in PARL influences mitochondrial content.
Not available
S-EPMC2829432 | biostudies-literature
UnknownThe mitochondrial protease PARL is required for spermatogenesis.
Not available
S-EPMC10770312 | biostudies-literature
UnknownInsights into the catalytic properties of the mitochondrial rhomboid protease PARL.
Not available
S-EPMC7966987 | biostudies-literature
UnknownPARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome.
Not available
S-EPMC6320509 | biostudies-literature
UnknownPARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson's disease.
Not available
S-EPMC12501375 | biostudies-literature
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