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ProteomicsHigH-ratiO partiaL proteolysiS with carriER proteome (HOLSER) Enables Global Structure Profiling and Site-resolved Elucidation of Ligand-Protein Interactions
Understanding how cellular proteins interact with their environment, including endogenous and exogeneous molecules, is critical for elucidating mechanisms of cellular regulation and drug action. Partial proteolysis-based techniques offer peptide-level resolution of ligand-induced conformational chan...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD077592 | Pride
Proteomics Ligand-protein interaction Partial proteolysis Lc-ms-ms 
ProteomicsHigH-ratiO partiaL proteolysiS with carriER proteome (HOLSER) Enables Global Structure Profiling and Site-resolved Elucidation of Ligand-Protein Interactions
Understanding how cellular proteins interact with their environment, including endogenous and exogeneous molecules, is critical for elucidating mechanisms of cellular regulation and drug action. Partial proteolysis-based techniques offer peptide-level resolution of ligand-induced conformational chan...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD069119 | Pride
Proteomics Tmt Drug traget deconvolution Lc-ms Machanism of action Partial proteolysis 
UnknownHCFC1 variants in the proteolysis domain are associated with X-linked idiopathic partial epilepsy: Exploring the underlying mechanism.
Not available
S-EPMC10235798 | biostudies-literature
UnknownProduct inhibition in native-state proteolysis.
Not available
S-EPMC4216078 | biostudies-literature
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019795 | Pride
Mitosis Mitotic exit Proteolysis Cell cycle Apc/c Proteome 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019791 | Pride
Proteomics Mitosis Mitotic exit Proteolysis Cell cycle Apc/c 
UnknownPartial proteolysis improves the identification of the extracellular segments of transmembrane proteins by surface biotinylation.
Not available
S-EPMC7264363 | biostudies-literature
ProteomicsLarge-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins using Limited Proteolysis
Conformational changes in proteins can lead to disease. Thus, methods for identifying conformational changes in proteins can further improve our understanding and facilitate detection of disease states. Here we combine limited proteolysis (LiP) with Stable Isotope Labeling with Amino Acids in Cell ...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD005210 | Pride
Proteomics Limited proteolysis Mass spectrometry Silac Mcf-10a Mcf-7 Protein folding 
ProteomicsA map of protein-metabolite interactions reveals principles of chemical communication
Application of a novel mass spectrometry-based high-throughput workflow (LiP-SMap) and data resource based on limited proteolysis (LiP) of complex samples. Proteome-wide limited proteolysis sites were obtained in different conditions to infer ligand-induced and protein-protein interaction induced co...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2018-01-04 | PXD006543 | Pride
Small molecules Limited proteolysis Lip-smap Dia-ms E.coli 
UnknownDevelopment of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders.
Not available
S-EPMC12471865 | biostudies-literature
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