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MetabolomicsUntargeted Metabolomics of Wheat Fielder, TaPDK1-OE, and pdk1 Lines under Alkaline Salt Stress
An untargeted metabolomics study was performed on wheat plants, including the wild-type cultivar Fielder, TaPDK1-overexpression (TaPDK1-OE) lines, and pdk1 mutant lines. Plants were grown under either normal conditions (control groups) or exposed to alkaline salt stress for 1 or 3 days (experimental...
2026-04-26 | MTBLS14380 | MetaboLights
TranscriptomicsPDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
Although 3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been predominately linked to PI3K-AKT pathway, it may also evoke additional signaling outputs to promote tumorigenesis. Here we report that PDK1 directly induces phosphorylation of Polo-like kinase 1 (PLK1), which in turn induces Myc ...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-30669 | biostudies-arrayexpress
TranscriptomicsExpression data from MMTV-PDK1 transgenic mice
The role of PDK1 on mammary tumorigenesis and its interaction with PPARdelta, was assessed. Transgenic mice were generated in which PDK1 was expressed in the mammary epithelium. We used microarrays to analyse global gene expression changes in MMTV-PDK1 transgenic mice versus wild-type mice and deter...
ORGANISM(S): Mus musculus 
2011-02-05 | E-GEOD-27083 | biostudies-arrayexpress
TranscriptomicsGene expression profile in melanomas from Pdk1-inactivated BrafV600E::Pten-/- mice
Gene expression profiling was performed to access the changes in gene expression in melanomas from Pdk1-inactivated Brafv600E::Pten-/- mice. The expression profiles of the BrafV600E::Pten-/-::Pdk1-/- were compared to the BrafV600E::Pten-/-::Pdk+/+ genotypes. The analysis has identified several imp...
ORGANISM(S): Mus musculus 
2013-09-17 | E-GEOD-42187 | biostudies-arrayexpress
ProteomicsHydrogen Deuterium Exchange of PDK1
This project consisted of three HDX-MS experiments. First, we compared the dimeric PDK1(SKD-PIF) to monomeric PDK1(SKD) and mapped the differences in deuterium incorporation onto the dimer model. We then compared the deuterium incorporation kinetics for the kinase (PDK1(SKD)) and PH (PDK1(PH) domain...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027401 | Pride
Hdx-ms pdk1 hdx 
TranscriptomicsTranscriptional effects of lentiviral vector-mediated PDK1 gene silencing in ovarian cancer xenografts
This experiment was designed to investigate the effect of PDK1 silencing on tumor growth, metabolism, and microenvironment modulation in vivo. Tumors were established in NOD/SCID mice by subcutaneous (s.c.) injection of an highly glycolytic ovarian cancer cell line (OVCAR3) transduced with lentivira...
ORGANISM(S): Homo sapiens 
2020-12-31 | E-MTAB-9877 | biostudies-arrayexpress
ProteomicsCross-link mass spectrometry reveals conformational changes within the N lobe and the activation loop of PDK1 upon dimerization
Cross-linking mass spectrometry analysis of the PDK1 kinase domain dimer that undergoes trans-autophosphorylation.
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031827 | Pride
Pip3 Dimerization Phosphorylation Kinase Pdk1 
ProteomicsS6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions
Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains largely elusive. Here we report that ribosomal ...
ORGANISM(S): Homo Sapiens 
PXD028167 |
GenomicsErk stimulation in PDK1 knockout cells
Erk stimulation in PDK1 knockout cells
PRJNA544000 | ENA
GenomicsRegulation of Tfh differentiation by PDK1
Regulation of Tfh differentiation by PDK1
PRJNA648089 | ENA
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