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In the current project we have carried out the first proteogenomic analysis of a parasitic helminth. This has allowed us to significantly improve the genome annotation and provide a robust characterisation of the ES proteome from the adult N. americanus. Our findings show important information on k...
ORGANISM(S): Necator americanus 
2019-09-26 | PXD010669 | Pride
The role of infection in erythropoietic dysfunction is poorly understood. In children with P. falciparum malaria, the by-product of hemoglobin digestion in infected red cells (hemozoin) is associated with the severity of anemia which is independent of circulating levels of the inflammatory cytokine ...
ORGANISM(S): Homo sapiens 
Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and ...
ORGANISM(S): Macaca mulatta 
Despite the clear role of adult secreted and tegumental proteins as well as egg proteins in host-parasite interactions, there has not been any in-depth proteomic analysis of these or other Schistosoma haematobium proteomes. In the current project we have carried out the first comprehensive proteomic...
ORGANISM(S): Schistosoma haematobium 
2019-04-09 | PXD011137 | Pride
A WTCCC2 project genome-wide study for pharmacogenomic response to statins (PR) in individuals from Scotland.
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