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ProteomicsHuman cancer cell MCF-7 IP-PTEN MS
The MCF-7 cells were lysed using RIPA lysis buffer with a high salinity content to break out non-covalent binding of proteins. Then IP under partially denaturing conditions was performed and demonstrated that anti-PTEN precipitates were detected as smear bands, then mass spectrometry analysis of the...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD021544 | Pride
Human Breast cancer Pten Ms 
ProteomicsMCF-7 PTEN-Nedd8 IP-MS
We intended to elucidate the underlying mechanism of PTEN-Nedd8 in tumorigenesis. So, we firstly employed affinity purification and mass spectrometry to interrogate PTEN-Nedd8 interactome in nucleus.
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD011395 | Pride
Human Breast cancer cell Nedd8 Pten Ip-ms 
ProteomicsMCF-7 Flag-need8 IP-MS
To allow the proteomic identification of proteins modified with Nedd8, we firstly employed affinity purification and mass spectrometry to interrogate Nedd8 interactome.
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD011368 | Pride
Human Breast cancer cell Ip-ms Mcf-7 
ProteomicsDeacetylation Induced Nuclear Condensation of HP1γ Promotes Multiple Myeloma Drug Resistance
Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during drug resistance, but the underlying mechanisms are not fully understood. Here we demonstrate that different proteins and their acetylation modification r...
ORGANISM(S): Homo Sapiens 
2023-02-20 | PXD040298 |
MetabolomicsLipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectromet...

2017-04-26 | MTBLS352 | MetaboLights
TranscriptomicsTranscriptome sequencing of naked mole rat, Heterocephalus glaber
Deep sequencing of mRNA from naked mole rat Analysis of ploy(A)+ RNA of different specimens: brain, kidney, liver from new born , 4 years old , 20 years old and 4 years old hypoxia-exposed naked mole rat
ORGANISM(S): Heterocephalus glaber 
2011-10-12 | E-GEOD-30337 | biostudies-arrayexpress
ProteomicsProtein mass spectrum analysis of gastrocnemius from CKD and NC mice
As for gastrocnemius (CKD vs. NC =4 vs. 4), the protein was extracted by homogenate and SDT lysis. Next, we did the following steps: SDS-PAGE separation, Filter-aided sample preparation (FASP Digestion), TMT labeling, peptide fractionation with reversed-phase (RP) chromatography and mass spectrometr...
ORGANISM(S): Mus Musculus 
2024-08-25 | PXD055326 |
ProteomicsProtein mass spectrum analysis of kidney tissue from CKD and NC mice
Protein mass spectrum analysis of kidney tissue from CKD and NC mice
ORGANISM(S): Mus Musculus 
2024-08-25 | PXD055325 |
ProteomicsProtein mass spectrum analysis of serum from CKD and NC mice
As for serum (CKD vs. NC =4 vs. 4), the protein was extracted by homogenate and SDT lysis. We utilized immunoaffinity depletion of serum high-abundance proteins. Next, we did the following steps: SDS-PAGE separation, Filter-aided sample preparation (FASP Digestion), TMT labeling, peptide fractionati...
ORGANISM(S): Mus Musculus 
2024-08-25 | PXD055324 |
ProteomicsGIST proteome dataset(Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups)
Gastrointestinal stromal tumor (GIST) is a common sarcoma of gastrointestinal tract (GIT) with high metastatic and recurrence rates, but the proteomic features are still less understood. Here we performed systematic quantitative proteome profiling of GIST from 13 patients classified into very low/lo...
ORGANISM(S): Homo Sapiens 
2019-01-29 | PXD011299 |
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