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ProteomicsImmunoprecipitated PARP1 interactome
Poly-(ADP-ribose) polymerase inhibitors (PARPi) elicit anti-tumour activity in homologous recombination defective cancers by promoting cytotoxic, chromatin-bound, “trapped” PARP1 DNA lesions. How cells process trapped PARP1 remains unclear. By exploiting wild-type or trapping-resistant PARP1 transge...
ORGANISM(S): Homo sapiens (Human) 
2021-10-05 | PXD024337 | Pride
Trapped parp1 Breast cancer Parp1 Rime Vcp Apex2 proximity labelling 
ProteomicsPARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-B-regulated immune response.
Oncolytic Reovirus type 3 Dearing (RT3D), is a naturally occurring double-stranded (ds) RNA virus that is under development as an oncolytic immunotherapy We used an unbiased high-throughput cytotoxicity screen of different targeted therapeutic agents with the aim of identifying potential drug-viral ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-01 | PXD047621 | Pride
Reovirus Parp inhibition Proteome Death inducing signaling complex (disc) Rig-i Nf-b Oncolytic virus Tmt Talazoparib Ifn Reovirus Type 3 dearing (rt3d) Cancer 
ProteomicsHORMAD1 interactome by affinity purification-mass spectrometry
HORMAD1 is aberrantly expressed in 60% of triple-negative breast cancers and associates with signatures of genomic instability. Aberrant expression of HORMAD1 in mitotic cells leads to defects in spindle assembly checkpoint. HORMAD1 affinity purification-mass spectrometry interactome mapping in mito...
ORGANISM(S): Homo sapiens (Human) 
2025-11-11 | PXD023666 | Pride
Breast cancer Mitosis Spindle assembly checkpoint Hormad1 Aurora b 
ProteomicsLocalisation of the Golgi pH regulator GPR89 extends to the endoplasmic reticulum and confers selective dependency in breast cancer
Identification of targetable biology in breast cancer is an important unmet need, particularly for triple negative breast cancer (TNBC) where outcomes are poor and there are few licensed targeted therapies. Here, we identify the anion channel GPR89 as a novel breast cancer oncogene relevant in TNBC ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD031422 | Pride
Gpr89 Triple negative breast cancer Er stress Ire1a 
UnknownSAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
Not available
S-EPMC3924925 | biostudies-literature
UnknownGenome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.
Not available
S-EPMC7843618 | biostudies-literature
UnknownA complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study.
Not available
S-EPMC4832072 | biostudies-literature
UnknownIbrutinib versus ofatumumab in previously treated chronic lymphoid leukemia.
Not available
S-EPMC4134521 | biostudies-literature
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
UnknownWhole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.
Not available
S-EPMC9649442 | biostudies-literature
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