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ProteomicsAP-MS of replisomes from S. cerevisiae in S phase and after unscheduled G1 replication
Interfering with once-per-cell-cycle regulation of DNA replication initiation generates genome instability through over-replication and has been linked to early stages of cancer development. Here, we engineered different systems in budding yeast to induce over-replication in G1 and investigated its ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-11 | PXD035629 | Pride
Dna replication Gins complex 
ProteomicsDbf4-dependent kinase (DDK) and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis
DNA repair by homologous recombination is under stringent cell cycle control. This includes the last step of the reaction, disentanglement of DNA joint molecules (JMs). Previous work has established that JMs resolving nucleases are activated specifically at the onset of mitosis. In case of budding y...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-01-21 | PXD005356 | Pride
Ddk Yeast Dna repair 
ProteomicsPhosphoproteomic dataset comparing wild type, bob1-1 and bob1-1dbf4∆ cells in M-phase arrested S.cerevisiae.
DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, repair pathway choice – the cellular decision making underlying DSB repair – occurs at the level of DSB resection and is controlled by the cell cycle. Upon cell cycle-dependent activation, cyclin-dependent kinases (C...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-15 | PXD042607 | Pride
Ddk Dbf4-cdc7 Cell-cycle Saccharomyces cerevisiae 
ProteomicsA SAM key domain required for enzymatic activity and allosteric activation of the Fun30 nucleosome remodeler
Fun30 is the prototype of the Fun30-SMARCAD1-ETL sub-family of nucleosome remodelers involved in DNA repair and gene silencing. These proteins appear to act as single subunit nucleosome remodelers, but their molecular mechanisms are, at this point, poorly understood. Using multiple sequence alignmen...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-18 | PXD037249 | Pride
Sam Fun30 Yeast Chromatin Resection Regulation Key 
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