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ProteomicsChemical mixture effects on the simplified human intestinal microbiota (SIHUMIx): Assessing Bisphenols and PFAS at environmentally realistic concentrations
The gut microbiota in our intestinal tract metabolizes non-digestible compounds into essential nutrients and signaling molecules (i.e. short-chain fatty acids), affecting our immune system and the development of various human diseases. Ingested environmental contaminants (xenobiotics) can disrupt th...
ORGANISM(S): Blautia producta ATCC 27340 = DSM 2950 Anaerostipes caccae Clostridium butyricum DSM 10702 Escherichia coli str. K-12 substr. MG1655 Bacteroides thetaiotaomicron Bifidobacterium longum subsp. longum Erysipelatoclostridium ramosum DSM 1402 Lactobacillus plantarum subsp. plantarum 
2024-06-13 | PXD048273 | Pride
Scfa Continuous bioreactor model system Bisphenols Gut microbiota Pfas Microbiome-dependent toxicity Metaproteomics 
GenomicsEnvironmentally relevant concentrations of individual per- and polyfluoroalkyl substances (PFAS) and a PFAS mixture impact proliferation and gene transcription in a human myometrial cell line.
Environmentally relevant concentrations of individual per- and polyfluoroalkyl substances (PFAS) and a PFAS mixture impact proliferation and gene transcription in a human myometrial cell line.
PRJNA1174757 | ENA
TranscriptomicsEnvironmentally relevant concentrations of individual per- and polyfluoroalkyl substances (PFAS) and a PFAS mixture impact proliferation and gene transcription in a human myometrial cell line.
Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants of concern due to their persistence and potential adverse health effects. Epidemiological studies have linked PFAS with an increased risk of uterine diseases including fibroids however, the mechanisms involved remain to be elu...
ORGANISM(S): Homo sapiens 
2024-10-18 | GSE279836 | GEO
TranscriptomicsAn environmentally relevant mixture of Perfluoroalkyl Substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells
Perfluoroalkyl substances (PFAS) are a group of synthetic chemicals that are resistant to biodegradation and are environmentally persistent. PFAS are found in many consumer products including non-stick cookware, food packaging materials, upholstery, and personal care products. Accordingly, PFAS are ...
ORGANISM(S): Homo sapiens 
2024-07-03 | GSE246371 | GEO
GenomicsAn environmentally relevant mixture of Perfluoroalkyl Substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells
An environmentally relevant mixture of Perfluoroalkyl Substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells
PRJNA1032615 | ENA
TranscriptomicsExposure of Ldlr-/- mice to a PFAS mixture increased circulating cholesterol and decreased bile acid excretion with concurrent increases in male ileal ASBT
Background: Previous epidemiological studies have repeatedly found per- and polyfluoroalkyl substances (PFAS) exposure associated with higher circulating cholesterol, one of the greatest risk factors for development of coronary artery disease. The main route of cholesterol catabolism is through its ...
ORGANISM(S): Mus musculus 
2024-08-14 | GSE263158 | GEO
UnknownAdsorption and Dynamic Characteristics of PFAS Mixtures with Kaolinite: Molecular Insights into the Impact of Chain Length and Functional Group.
Not available
S-EPMC12288066 | biostudies-literature
GenomicsExposure of Ldlr-/- mice to a PFAS mixture increased circulating cholesterol and decreased bile acid excretion with concurrent increases in male ileal ASBT
Exposure of Ldlr-/- mice to a PFAS mixture increased circulating cholesterol and decreased bile acid excretion with concurrent increases in male ileal ASBT
PRJNA1095993 | ENA
ProteomicsExposure to a PFOA, PFOS and PFHxS mixture during gestation and lactation alters the liver proteome in offspring of CD-1 mice
PFAS are persistent man-made chemicals considered to be emerging pollutants, with PFOA, PFOS, and PFHxS having associations with liver toxicity and steatosis. PFOA, PFOS, and PFHxS can undergo placental/lactational transfer, however, little is known about the impact of PFAS mixtures during the devel...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-09 | PXD052106 | Pride
Pfoa Cd-1 mouse Pfos Maternal exposure Perinatal Proteome Hepatotoxicity Liver Pfas mixture Pfhxs 
UnknownEnvironmentally relevant concentrations of individual per- and polyfluoroalkyl substances (PFAS) and a PFAS mixture impact proliferation, migration, and gene transcription in a human myometrial cell line.
Not available
S-EPMC12424527 | biostudies-literature
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