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ProteomicsThe E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to infection
Phagocytosis is an essential process for the microbicidal function of professional phagocytes, in which phagosome maturation plays a critical role. Macrophage activation by interferons (IFN) increases their microbicidal activity, but delays phagosomal maturation. Here, we investigated the role of ub...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-20 | PXD026843 | Pride
Macrophage Phagosome Rnf115 Ubiquitin E3-ligase 
ProteomicsPacific oyster phagosome LC-MSMS
Phagosomes are task-force organelles of innate immune systems responsible for the recognition, processing, and ultimately destruction of invading microorganisms. Among invertebrate and vertebrate species, evolutionary diversity and continuity abound in the protein machinery executing this coordinate...
ORGANISM(S): Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 
2020-04-27 | PXD015810 | Pride
Innate immunity Actin remodeling Oyster Phagosome 
ProteomicsComaprison of the phagosome proteome of bone marrow-derived macrophages and RAW264.7
Macrophages are important immune cells operating at the forefront of innate immunity by taking up foreign particles and microbes through phagocytosis. The RAW 264.7 cell line is commonly used for experiments in the macrophage and phagocytosis field. However, little is known how its functions compare...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-08 | MSV000084938 | MassIVE
ProteomicsTemporal and ligand effects on phagosome maturation
Systems biology analysis of temporally-resolved phagosome proteomes following uptake via key phagocytic receptors Macrophages operate at the forefront of innate immunity, and their discrimination of pathogenic versus “self” particles is critical for a number of responses including efficient pathogen...
ORGANISM(S): Mus musculus (Mouse) 
2015-09-10 | PXD000772 | Pride
Phagocytosis Macrophage Proteomics Mtraq Phagosome 
UnknownThe phagosome proteome: insight into phagosome functions.
Not available
S-EPMC2193653 | biostudies-literature
ProteomicsPhagosome proteome of mock and Atg8 silenced Entamoeba histolytica strains
The enteric protozoan parasite Entamoeba histolytica have high phagocytic ability. Phagocytosis is also important for the pathogenicity of this parasite; molecular mechanisms of phagocytosis and phagosome maturation is focused. Atg8 is well studied autophagy marker protein. We previously shown that ...
ORGANISM(S): Entamoeba histolytica HM-1:IMSS-A 
2022-10-20 | PXD034376 | Pride
Autophagy Lysosome Atg8 Entamoeba histolytica Serum coated beads Phagosome 
ProteomicsTPL-2 kinase induces phagosome acidification to promote macrophage killing of Staphylococcus aureus
Tumor Progression Locus 2 (TPL-2) kinase mediates Toll-like Receptor (TLR) activation of ERK1/2 and p38-alpha MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase-independent regulatory function for TPL-2 in phagosome matur...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD020401 | Pride
Macrophage  phagosome Staphylococcus aureus  tpl-2  v-atpase 
UnknownThe Mycobacterium bovis bacille Calmette-Guerin phagosome proteome.
Not available
S-EPMC2808266 | biostudies-literature
OtherA Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions.
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00551 PASS00551]]. File: SBEP_STM_subcell-53c_14Jan11_Doc_10-09-53.mzml. Published as part of . From the Abstract: {{i}} Towards developing a systems-level pathobiological understanding of Salmonella enterica, we performed a subcellular...
ORGANISM(S): Salmonella_phage_c341_uid39795,salmonella_phage_e1_uid29079,salmonella_phage_epsilon34_uid33779,salmonella_phage_fels_1_uid29267,salmonella_phage_phisg_jl2_uid30063,salmonella_phage_se1_uid33483,salmonella_phage_setp3_uid19157,salmonella_phage_st64b_uid14228, Salmonella_enterica_serovar_typhimurium_14028s 
GPM32310003265 | GPMDB
ProteomicsTPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria
Tumor Progression Locus 2 (TPL-2) kinase mediates Toll-like Receptor (TLR) activation of ERK1/2 and p38 MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase-independent regulatory function for TPL-2 in phagosome maturation,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-24 | PXD020247 | Pride
Macrophage Bacteria Tpl-2 V-atpase Staphylococcus aureus Dmxl1 Phagosome 
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