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ProteomicsPhosphatidylinositol 3-phosphate (PI3P) interactome analysis under varied iron conditions in Candida glabrata.
The project is aimed at identifying proteins that interact with PI3P in low-iron, regular-iron and high-iron grown Candida glabrata cells.
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2024-02-19 | PXD042058 | Pride
Bathophenanthroline disulfonate (bps) Lc-ms/ms. Candida glabrata Phosphatidylinositol 3-phosphate (pi3p) 
ProteomicsIn vitro reconstitution of Sgk3 activation by phosphatidylinositol-3-phosphate
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid 19 phosphatidylinositol-3-phosphate (PI3P) downstream of growth factor signaling and 20 by Vps34-mediated PI3P production during autophagy. Upregulation of Sgk3 activity 21 has been linked to a number of human cance...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025327 | Pride
Kinase Sgk3 Hdx-ms Pi3p 
ProteomicsLabel-free quantitative plasma membrane proteome analysis of Candida glabrata wild-type and Cgvps34∆ (lacks phosphatidylinositol 3- phosphate kinase, CgVps34) strains. Label-free quantitative plasma membrane proteome analysis of Candida glabrata wild-type and Cgvps34∆ (lacks phosphatidylinositol 3- phosphate kinase, CgVps34) strains.
The project is aimed at characterizing the effect of loss of phosphatidylinositol 3- phosphate kinase (CgVps34) on the plasma membrane proteome of Candida glabrata.
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2024-02-19 | PXD042056 | Pride
Plasma membrane (pm) Pi3k (phosphatidylinositol 3- phosphate kinase) Candida glabrata Label-free quantitative proteome analysis 
ProteomicsNuclear Phosphatidylinositol 3-Phosphate Produced by Beclin-1/Vps34 Directly Orchestrates DNA Mismatch Repair
DNA mismatch repair (MMR) is essential for maintaining genome integrity, yet its regulation by non-protein biomolecules remains poorly understood. Here, we uncover nuclear phosphatidylinositol 3-phosphate (PI3P) as a previously unrecognized lipid mediator of MMR. PI3P, canonically produced by the Be...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD066473 | Pride
Autophagy Ip-ms Dna mismatch repair Genome stability 
UnknownPI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase.
Not available
S-EPMC10267561 | biostudies-literature
UnknownIn vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Not available
S-EPMC8318898 | biostudies-literature
UnknownEndosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.
Not available
S-EPMC5270463 | biostudies-literature
ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
ProteomicsA Phosphoinositide Interacting Protein Coordinates Stress Precursor Activities
Samd14 coordinates stem cell factor/Kit receptor signaling and is crucial for the survivalof red blood cel precursors within anemia contexts. Here we present new findings that Samd14 expression is needed to maintain balanced autophagy in red blood cell precursors following acute anemia. Autophagy ge...
ORGANISM(S): Anemia Mus musculus (Mouse) 
2026-02-11 | PXD067716 | Pride
Autophagy Samd14 Red blood cells Phosphatidylinositol 3-phosphate 
UnknownEarly Endosomal Vps34-Derived Phosphatidylinositol-3-Phosphate Is Indispensable for the Biogenesis of the Endosomal Recycling Compartment.
Not available
S-EPMC8946653 | biostudies-literature
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