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MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
ProteomicsTargeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network
Cyclin-dependent kinase 9 (CDK9) coordinates signaling events that regulate RNA polymerase II (Pol II) pause-release states. It is an important co-factor for transcription factors, such as MYC, that drive aberrant cell proliferation when their expression is deregulated. CDK9 modulation offers an app...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD052300 | Pride
Cdk9 Myc Transcription Protacs Ribosome biogenesis 
ProteomicsPathological deficit of Cystatin B impairs synaptic plasticity in EPM1 human cerebral organoids
Cystatin B (CSTB) is a small protease inhibitor involved in cell proliferation and migration, and composition of extracellular matrix during brain development. Loss-of-function mutations in the gene encoding CSTB cause progressive myoclonic epilepsy 1 (EPM1). We previously demonstrated that CSTB is ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD041125 | Pride
Epm1  cystatin b  synaptic plasticity 
ProteomicsCystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy
Progressive myoclonus epilepsy (PME) of Unverricht-Lundborg-type (EPM1) is an autosomal recessive neurodegenerative disorder with the highest incidence of PME worldwide. Mutations in the gene encoding cystatin B (CSTB) are the primary genetic cause of EPM1. Here, we investigate the role of CSTB duri...
ORGANISM(S): Homo sapiens (Human) 
2020-05-13 | PXD018021 | Pride
Cystatin b  human cerebral organoids  progressive myoclonus epilepsy  mass spectrometry 
ProteomicsThe pan-Sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line
The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD017508 | Pride
Sirtuins Leukemia Human Mitochondria Orbitrap q-exactive 
ProteomicsHuman Histone Fragments Display Antibacterial Properties against Pseudomonas aeruginosa
Differential proteomic experiment using Pseudomonas aeruginosa in the presence and the absence of Human Histone Fragments.
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2026-09-14 | PXD080063 | Pride
Human histones Antibacterial activity H1.2 peptide Neutrophil extracellular traps (nets) Outer membrane biogenesis Immunomodulatory effects Antimicrobial peptides (amps) Pseudomonas aeruginosa 
ProteomicsSolute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis
Ulcerative colitis (UC) patients have a greater risk of developing colorectal cancer through inflammation-dysplasia-carcinoma sequence of transformation. The histopathological diagnosis of dysplasia is therefore of critical clinical relevance, but dysplasia may be difficult to distinguish from infla...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD018679 | Pride
Dysplasia associated to inflammation Colorectal neoplasia Label-free proteomics 
ProteomicsProteomics reveals PFOS-induced alteration of lipid utilization and xenobiotic metabolism in a model of PFOS-augmented diet-induced fatty liver
Perfluorooctanesulfonic acid (PFOS) is a persistent, bio-accumulative pollutant that has been used for the last 60+ years in numerous industrial and commercial applications. In mice, PFOS administration is known to induce hepatomegaly and hepatic steatosis. The aim of the present study was to evalua...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-30 | PXD016161 | Pride
Perfluorinated compounds Pfos Proteomics Liver High fat diet Weight loss Nafld 
ProteomicsMouse kidney and cell lines LC-MS/MS
Zinc (Zn) is an essential micronutrient and cofactor for up to 10% of proteins in living organisms. During Zn limitation, specialized enzymes called metallochaperones are predicted to allocate Zn to specific metalloproteins. This function has been putatively assigned to G3E GTPase COG0523 proteins,...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD031516 | Pride
Mouse Targeteed Shotgun Zinc 
ProteomicsRNA instability in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA binding protein TDP-43. TDP-43 regulates RNA homeostasis, but it remains unclear whether RNA stability is affected in these disorders. We use Bru-seq and BruChase-seq to assess...
ORGANISM(S): Homo sapiens (Human) 
2018-07-24 | PXD009969 | Pride
Rna Tmt 10plex Amyotrophic lateral sclerosis Frontotemporal dementia Stem cells Stability Lc-ms/ms 
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