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UnknownComplete Genome Sequences of Mycobacteriophages Clautastrophe, Kingsolomon, Krypton555, and Nicholas.
Not available
S-EPMC5679797 | biostudies-literature
ProteomicsPhosphoproteomic Analysis of Lethal Castration Resistant Prostate Cancer Reveals Patient but not Metastatic Site Heterogeneity of Tyrosine Kinase Activation
Tissue lysis was performed as previously described (Drake, J.M., et al. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A 109, 1643-1648 (2012)) Briefly, greater than 300 mg of frozen tumor mass was homogenized and sonicated in urea...
ORGANISM(S): Homo sapiens (Human) 
2013-11-21 | PXD000238 | Pride
Tyrosine phosphorylation Human Prostate cancer 
ProteomicsMitoxantrone impacts on proteoform abundance in HR proficient and deficient ovarian cancer cells
Mitoxantrone (MX) is regularly used to treat several cancers, yet despite its long history in the clinic, recent studies continue to unveil novel protein targets that may contribute to the cytotoxic effects of the drug, as well as potential non-canonical antitumor activity. A better understanding of...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD069401 | Pride
Ovarian cancer Mitoxantrone 
UnknownEfficacy of Hair Total Mercury Content as a Biomarker of Methylmercury Exposure to Communities in the Area of Artisanal and Small-Scale Gold Mining in Madre de Dios, Peru.
Not available
S-EPMC8707462 | biostudies-literature
ProteomicsComparison of microglial proteomes of MACS and FACS-based purified CD11b+ microglia
Background Proteomic characterization of microglia has been limited by low yield and contamination by non-microglial proteins by magnetic-activated cell sorting (MACS) enrichment strategies. To determine whether a fluorescent-activated cell sorting (FACS)-based strategy overcomes these limitations,...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-11 | PXD015652 | Pride
Mouse acutely purified brain-associated microglia Tmt Macs Facs 
ProteomicsRat Cortical Primary Neuronal Culture with NRN1 Protein Treatment
Cortical rat neuronal culture, lysis and proteolytic digestion Primary rat cortical neurons were generated from E18 Sprague-Dawley rat embryos with minor modifications (Swanger, Mattheyses et al. 2015, Henderson, Greathouse et al. 2019). Neurons were cultured at a density of 4x105 cells per well in...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD040867 | Pride
Rat primary cortical neurons Nrn1 Neuroproteomics 
ProteomicsActivity-based profiling of Shigella virulence factor OspF in human cells
Phosphothreonine lyases are a small family of bacterial virulence factors secreted into host cells during infection by certain Gram-negative pathogens. This family of enzymes is known for its unique mechanism of silencing host immune signaling via the irreversible β-elimination of phosphothreonine (...
ORGANISM(S): Homo sapiens (Human) 
2026-02-27 | PXD073985 | Pride
Ospf Dehydrobutyrine Chemoproteomics Phosphothreonine lyase Shigella Bacterial infection Human 
ProteomicsGlobal quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
Patients with Alzheimer’s disease (AD) and Parkinson disease (PD) often have overlap in brain neuropathology and clinical presentation suggesting that these two diseases share common underlying mechanisms. Currently, the molecular events linking AD and PD are incompletely understood. Utilizing 10-p...
ORGANISM(S): Homo sapiens (Human) 
2018-02-07 | PXD007160 | Pride
Brain Tmt Human Sps Parkinson's Alzheimer's Lc-ms/ms 
ProteomicsDissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms
Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes and a bovine gastrointestinal (GI) isolate. Key genomic differences between bovine and human treponemes implicate microbial mechanisms t...
ORGANISM(S): Treponema sp. T19 Treponema pedis Treponema ruminis Treponema phagedenis Treponema medium Treponema sp. T320A 
2021-03-16 | PXD022419 | Pride
Bovine digital dermatitis Treponemes Shotgun lc msms 
UnknownGreater post-Neolithic wealth disparities in Eurasia than in North America and Mesoamerica.
Not available
S-EPMC5714260 | biostudies-literature
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