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TranscriptomicsGenes in unstable plaques
Transcriptional profiling of stable and unstable atherosclerotic plaque segments from human carotid endatrerectomies Objective Comparison of gene expression in stable versus unstable atherosclerotic plaque may be confounded by interpatient variability. The aim of this study was to identify differen...
ORGANISM(S): Homo sapiens 
2006-01-30 | E-TABM-190 | biostudies-arrayexpress
ProteomicsA Proteomic Atlas of Atherosclerosis: Regional Proteomic Signatures for Plaque Inflammation and Calcification
Background: Using proteomics, we strove to reveal novel molecular subtypes of human atherosclerotic lesions, study their associations with histology and imaging and relate them to long-term cardiovascular outcomes. Methods: 219 samples were obtained from 120 patients undergoing carotid endarterectom...
ORGANISM(S): Homo sapiens (Human) 
2023-11-15 | PXD031052 | Pride
Calcification Tmt-labelling Plaque Cardiovascular outcome prognosis Atherosclerosis Inflammation Carotid endarterectomy 
ProteomicsRegion-specific lipid markers of plaque outcome revealed by mass spectrometry imaging of human carotid atherosclerotic plaques
The goal of the project is the detection of region-specific lipid features that discriminate between symptomatic and asymptomatic human carotid atherosclerotic plaques by MALDI MSI.
ORGANISM(S): Homo sapiens (Human) 
2025-01-04 | PXD039822 | Pride
Atherosclerosis Maldi msi Lipids Plaque outcome 
MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
ProteomicsProtein expression patterns associated with sucrose-induced dysbiosis are conserved across taxonomically diverse oral microcosm biofilm models of dental caries.
The lesions of enamel caries can be considered as the outcome of dysbiotic changes in the biofilm community of supragingival dental plaque. Demineralization occurs as the cumulative outcome of repeated shifts towards a less diverse microbiota that produces and tolerates a low pH environment in tooth...
ORGANISM(S): Streptococcus mutans 19 
2016-01-04 | PXD003151 | Pride
Dental caries Metaproteomics Oral microbiome Galaxy-p Dysbiosis 
TranscriptomicsAcutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype- effect of gfap-/- and vim-/-
GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Reactive astrocytes with an increased expression of intermediate filament (IF) proteins Glial Fibrillary...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74614 | biostudies-arrayexpress
UnknownManagement and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study.
Not available
S-EPMC5524007 | biostudies-literature
UnknownExtracranial Carotid Plaque Hemorrhage Is Independently Associated With Poor 3-month Functional Outcome After Acute Ischemic Stroke-A Prospective Cohort Study.
Not available
S-EPMC8712340 | biostudies-literature
UnknownLipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation.
Not available
S-EPMC11255968 | biostudies-literature
UnknownSymptomatic atherosclerotic plaque progression in a first-generation carotid stent: management and 5-year clinical and imaging outcome-a case report.
Not available
S-EPMC8846173 | biostudies-literature
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