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ProteomicsMouse HiRIEF LCMS Proteomics of liver tissue - WT VS PolgA KO mutant
Mitochondrial dysfunction is implicated in aging and aging-related disorders, such as neurodegenerative diseases and stroke. To study the effects of progressive mitochondrial dysfunction, a homozygous knock-in mouse expressing a proof-reading deficient version of the nucleus-encoded catalytic subuni...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-05 | PXD047574 | Pride
Mouse Tmt10plex Liver Wild type Hirief Lcms Murine Polga knockout Wt Qexactive 
UnknownDaily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice.
Not available
S-EPMC11452303 | biostudies-literature
UnknownUnveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.
Not available
S-EPMC11449839 | biostudies-literature
UnknownHallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice.
Not available
S-EPMC7432580 | biostudies-literature
ProteomicsMouse HiRIEF LCMS Proteomics - Sedentary VS Exercise, WT VS PolgA mutant
Mitochondrial dysfunction is implicated in aging and aging-related disorders, such as neurodegenerative diseases and stroke. To study the effects of progressive mitochondrial dysfunction, a homozygous knock-in mouse expressing a proof-reading deficient version of the nucleus-encoded catalytic subuni...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-05 | PXD011741 | Pride
Exercise Polga Muscle Striatum Mouse Brain Lcms Hirief Cortex Wt Sedentary 
UnknownMitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny.
Not available
S-EPMC4669800 | biostudies-literature
TranscriptomicsRNA-Seq of Aged Polg Mutator Mouse Brains
We have performed both proteomic and transcriptomic analyses of the brains of one-year old Polg mutator mice. As part of this analysis, we generated RNA-Seq data from RNA isolated from one cerebral hemisphere of these mice. mRNA levels and protein abundance levels were compared in this study. 11 sa...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-55188 | biostudies-arrayexpress
TranscriptomicsMito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice
Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a failure of normal mitochondrial quality-control syste...
ORGANISM(S): Mus musculus 
2015-04-21 | E-GEOD-57761 | biostudies-arrayexpress
UnknownMitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A.
Not available
S-EPMC3488228 | biostudies-literature
UnknownImpact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition.
Not available
S-EPMC5905657 | biostudies-literature
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