Post translational modifications of histones

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Raymond H. Wittcoff Distinguished Professor and Head Department of Biochemistry and Molecular Biophysics Washington University School of Medicine St. Louis, MO 63110 (2)
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1 Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia (1)
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Centre for Epigenetics and Department of Biochemistry and Molecular Biology, University of Southern Denmark Campusvej 55 DK-5230 Odense M, Denmark (1)
Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Catalonia, Spain (1)
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Centre for Genomic Regulation (CRG), Barcelona, Spain (1)
Chair of chromatin replication and architecture, Institute of Cell Biology, University of Edinburgh, School of Biological Sciences Kings Buildings Roger Land Building, room 1.63 Alexander Crum Brown Road Edinburgh EH9 3FF, UK (1)
Departament de Bioquímica i Biologia Molecular, Universitat de València. C/ Dr. Moliner 50. 46100 Burjassot, València. Spain (1)
Department of Biochemistry and Microbiology University of Victoria, Canada (1)
Department of Biochemistry and Molecular Biology, Protein Research Group, University of Southern Denmark (1)

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Mitotic post-translational modifications of histones promote chromatin compaction in vitro

As histones undergo major changes in their post-translational modifications during mitotic entry, we speculated that the spectrum of cell cycle-specific histone modifications might contribute to chromosome compaction during mitosis. To test this hypothesis, we isolated core histones from interphase ...

ORGANISM(S): Gallus gallus (Chicken)

2018-10-24 | PXD007116 | Pride

Pathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples

Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)

2016-08-25 | MSV000080100 | MassIVE

Trypanosoma brucei histones are heavily modified with combinatorial post-translational modifications and mark Pol II transcription start regions with hyperacetylated H2A.

Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and display some unusual genomic and epigenetic properties that provide valuable insight into the early processes employed by eukaryotic ancestors to regulate chromatin-mediated functions. We sequenced Trypanosoma br...

ORGANISM(S): Trypanosoma brucei

2022-08-21 | PXD024574 | Pride

Combinatorial histone post-translational modification Transcription Epigenetics Trypanosoma brucei Histone hyperacetylation

Histone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map

In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly at the post-transcriptional level. However, our group has recently shown that h...

ORGANISM(S): Trypanosoma cruzi

2021-01-04 | PXD019104 | Pride

Post-translational modifications Trypanosoma cruzi Histone Trypanosomatids

Mitotic post-translational modifications of histones promote chromatin compaction in vitro.

Not available

S-EPMC5627050 | biostudies-literature

Systems level analysis of histone H3 post-translational modifications reveals features of PTM crosstalk in chromatin regulation

Chromatin structure and function is maintained by dynamic protein-protein and protein-nucleic acid interactions. Histones are a family of proteins that are abundant chromatin constituents and that carry numerous post-translational modifications (PTMs). Histone PTMs mediate a variety of biological ac...

ORGANISM(S): Mus musculus (Mouse)

2016-06-16 | PXD002560 | Pride

Post-translational modification crosstalk histone mass spectrometry proteomics

Lysine propionylation and butyrylation are novel post-translational modifications in histones.

Not available

S-EPMC2911958 | biostudies-literature

Analysis of Histones H3 and H4 Reveals Novel and Conserved Post-Translational Modifications in Sugarcane.

Not available

S-EPMC4520453 | biostudies-literature

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems

Histone post-translational modifications (PTMs) generate a complex combinatorial code that regulate gene expression and nuclear functions, and whose deregulation has been documented in different types of cancers. Therefore, the availability of relevant culture models that can be manipulated and that...

ORGANISM(S): Homo sapiens (Human)

2018-04-06 | PXD007235 | Pride

Tissue Histone post-translational modifications Cell culture Primary cells

Profiling post-translational modifications of histones in human monocyte-derived macrophages.

Not available

S-EPMC4582717 | biostudies-literature

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