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MetabolomicsIonic homeostasis, carbohydrate metabolism, and oxidative balance underlie wild soybean resistance to low potassium stress

The scarcity of potassium resources in farmland soils poses a major challenge to global food security. Wild soybean (Glycine soja), a valuable wild germplasm related to cultivated soybeans, is known for its high-stress resistance and adaptability. This study comprehensively compares two wild soyb...

2026-04-12 | MTBLS14256 | MetaboLights
ProteomicsSelective Binding of a Toxin and Phosphatidylinositides to a Mammalian Potassium Channel
G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Although studies have provided insight into these interactions, the mechanism of how these events are modulated by Gβγ and the binding affinity between PIPs ...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-02 | PXD012894 | Pride
Potassium channel Pip2 Lipid selectivity Lipid binding Girk2 Phosphorylation 
TranscriptomicsModulation of calcium activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker- like cells
Background: Ion channels are key determinants for the function of excitable cells but little is known about their role and involvement during cardiac development. Earlier work identified Ca2+-activated potassium channels of small and intermediate conductance (SKCas) as important regulators of neural...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-18660 | biostudies-arrayexpress
ProteomicsConfirmation of recombinant Calcium-activated potassium channel from Leishmania donovani
Calcium-activated potassium channels are important membrane proteins that help in maintaining the cellular physiology and cell signalling. Till date no Calcium-activated potassium channels have been identified in Leishmania donovani. It’s gene was cloned into pET vector and expressed in E. coli BL21...
ORGANISM(S): Leishmania sp. MHOM/IN/80/DD8 Leishmania donovani 
2021-05-11 | PXD019577 | Pride
Calcium-activated potassium channel Ion-channel Membrane protein 
MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
ProteomicsIdentification of proteins associated with Kv1.2 potassium channels.
Kv1.2 is a prominent voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. We explored multi-protein complexes containing Kv1.2 using mass spectrometry of immunoprecipitated samples. Proteins identified as candidate interactors wer...
ORGANISM(S): Homo sapiens (Human) 
2018-11-04 | PXD011010 | Pride
Potassium channel Kv1.2 Human Lcmsms 
ProteomicsProximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.
Microglia are resident immune cells of the brain and regulate its inflammatory state. In neurodegenerative diseases, microglia transition from a homeostatic state to a state referred to as disease associated microglia (DAM). DAM express higher levels of proinflammatory signaling molecules, like STAT...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-06 | PXD049433 | Pride
Proximity labeling Neurodegeneration Neuroinflammation Kv1.3 potassium channel Microglia 
ProteomicsKCMF1 links RAD6 to UBR4 and lysosome-mediated degradation
Raw mass spec. data files, converted peak lists and TPP results files for KCMF1 links RAD6 to UBR4 and lysosome-mediated degradation by Hong et. al, MCP 2014. RAD6 is a ubiquitin E2 protein with roles in a number of different biological processes. Here, using affinity purification coupled with mass ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-01 | MSV000078983 | MassIVE
GenomicsSlo2 potassium channel function depends on a SCYL1 protein
Slo2 potassium channel function depends on a SCYL1 protein
PRJNA593043 | ENA
TranscriptomicsEAG2 potassium channel with evolutionarily conserved function as a brain tumor target
Characterizing the impact of pharmacological and shRNA-mediated silencing of EAG2 in medulloblastoma. Medulloblastoma (MB) is the most common pediatric CNS malignancy. Previously, we demonstrated that overexpression of the ion channel EAG2, identified in a subset of histological and molecular subtyp...
ORGANISM(S): Homo sapiens 
2015-07-08 | GSE70576 | GEO
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