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Unknown (22939)
Genomics (565)
Transcriptomics (225)
Proteomics (118)
Metabolomics (20)
Models (12)
Other (7)
Clinical (5)
Methylation profiling (2)
Genomic (1)

Organisms

Homo sapiens (182)
Aerococcus urinae NBRC 15544 = CCUG 36881 (88)
Alteromonadales (88)
Bacteria (88)
Canis lupus familiaris (88)
Carya cathayensis (88)
Ectopseudomonas oleovorans CECT 5344 (88)
Ensifer adhaerens (88)
Enterococcus faecalis (88)
Globicatella sanguinis (88)
Halictus scabiosae (88)
Histomonas meleagridis (88)
Human immunodeficiency virus 1 (88)
Listeria monocytogenes (88)
Methylohalobius crimeensis 10Ki (88)
Mus musculus (88)
Olavius algarvensis sulfate-reducing endosymbiont (88)
Mus musculus (72)
Rattus norvegicus (24)
Sus scrofa (5)
Macaca mulatta (5)
Callithrix jacchus (3)
Macaca fascicularis (3)
Canis lupus familiaris (3)
Mus sp. (2)
Tupaia belangeri (1)
Cavia porcellus (1)
Mus (1)
Ovis aries (1)
Mus (1)

Organisms

Homo sapiens (218)
Mus musculus (151)
Rattus norvegicus (12)
Macaca fascicularis (7)
Macaca mulatta (7)
Canis lupus familiaris (4)
Sus scrofa (4)
Rhipicephalus haemaphysaloides (2)
Callithrix jacchus (2)
Bacteroides thetaiotaomicron VPI-5482 (1)
Macaca nemestrina (1)
Cavia porcellus (1)
Mus (1)
Ovis aries (1)
Tupaia belangeri (1)
Danio rerio (1)
mouse gut metagenome (1)

Repository

ENA (523)
geo (142)
biostudies-arrayexpress (112)
pride (88)
EGA (25)
MetaboLights (20)
MassIVE (16)
BioModels (12)
iProX (5)
PanoramaPublic (3)
jPOST (2)
dbGaP (1)
PAXDB (1)

Tissue

Cell culture (16)
Liver (10)
Lung (9)
Blood plasma (6)
Brain (6)
Kidney (6)
Blood (5)
Skin (5)
Blood serum (4)
Colon (4)
Epithelial cell (4)
Hepatocyte (4)
Spleen (4)
Bone marrow (3)
Heart (3)
Macrophage (3)
Monocyte (3)
B cell (2)
Cerebrospinal fluid (2)
Permanent cell line cell (2)
Primary cell (2)
Sciatic nerve (2)
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Blood cell (1)
Breast (1)
Breast cancer cell (1)
Cell suspension culture (1)
Cerebellum (1)
Embryonic cell (1)
T cell (1)

Disease

Colorectal Neoplasms (3)
Breast cancer (3)
Acquired metabolic disease (2)
Acute leukemia (2)
Diffuse midline glioma (2)
Disease free (2)
Oropharynx cancer (2)
Pancreatic ductal carcinoma (2)
Post-traumatic stress disorder (2)
MPIN (murine prostatic intraepithelial neoplasia) (1)
Glioma (1)
Neoplasms (1)
Cervix carcinoma (1)
Chronic lymphocytic leukemia (1)
Colon cancer (1)
Colorectal cancer (1)
Focal segmental glomerulosclerosis (1)
Glioblastoma (1)
Hepatocellular carcinoma (1)
Huntington Disease (1)
Idiopathic pulmonary fibrosis (1)
Lung adenocarcinoma (1)
Lymphoma (1)
Malignant mesothelioma (1)
Malignant neoplasm of ovary (1)
Metabolic dysfunction-associated steatotic liver disease (1)
Neuroblastoma (1)
Noonan syndrome (1)
Obesity (1)
Parkinson's disease (1)

Technology Type

Mass Spectrometry (88)
Shotgun proteomics (33)
Bottom-up proteomics (26)
Data-dependent acquisition (15)
Mass spectrometry (13)
Data-independent acquisition (13)
SWATH MS (7)
Affinity purification coupled with mass spectrometry proteomics (6)
Mass spectrometry assay (5)
DiaPASEF (4)
Top-down proteomics (4)
NMR spectroscopy (3)
HDMSE (2)
MSE (2)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2000, NextSeq 500, ILLUMINA (1)
Illumina HiSeq 2000 (1)
All-ion fragmentation (1)
Gel-based experiment (1)
Proteogenomics (1)
SRM/MRM (1)

Instrument Platform

Illumina NovaSeq 6000 (10)
Agilent High resolution C scanner (4)
Illumina HiSeq 2000 (4)
Q Exactive (4)
Illumina HiSeq 4000 (2)
NextSeq 500 (2)
DNBSEQ Eukaryotic Stranded Transcriptome library preparation- Stranded mRNA Library (1)
MSI GP76 Leopard 10UE-060ES Intel Core i7-10870H/16GB/1TB SSD/RTX 3060/17.3\ (1)
Manual protocol (1)
Mastercycler pro S Thermocyler (Eppendorf); 2100 Bioanalyzer (Agilent) (1)
2100 Bioanalyzer (Agilent); Axio Imager.Z2 (ZEISS) (1)
CryoStar NX70 Cryostat (Epredia) (1)
Affymetrix GeneChip Scanner 3000 7G (1)
NA (1)
NextSeq 2000 (1)
DNBSEQ-T7 (1)
Illumina HiSeq 2500 (1)
6490 Triple Quadrupole LC/MS (1)
Agilent 6550 LC-MS/MS (1)
LTQ Orbitrap (1)
LTQ Orbitrap Elite (1)
LTQ Orbitrap Velos (1)
Orbitrap Eclipse (1)
Orbitrap Exploris 480 (1)
Orbitrap Fusion (1)
Orbitrap Fusion ETD (1)
Orbitrap Fusion Lumos (1)
Q Exactive HF (1)
Q Exactive Plus (1)
Synapt G2-S HDMS (1)

Publication Date

2025 (76)
2024 (58)
2026 (45)
2023 (38)
2013 (33)
2022 (22)
2021 (21)
2014 (19)
2012 (16)
2020 (13)
2015 (11)
2018 (9)
2016 (9)
2011 (7)
2010 (7)
2017 (6)
2008 (5)
2019 (2)

UNIPROT ID/AC

1433B_MOUSE (1)
1433E_MOUSE (1)
1433F_MOUSE (1)
1433G_MOUSE (1)
1433S_MOUSE (1)
1433T_MOUSE (1)
1433Z_MOUSE (1)
2A5A_MOUSE (1)
2AAA_MOUSE (1)
2AAB_MOUSE (1)
2ABA_MOUSE (1)
3BHS6_MOUSE (1)
3HIDH_MOUSE (1)
4F2_MOUSE (1)
5NTD_MOUSE (1)
6PGD_MOUSE (1)
6PGL_MOUSE (1)
A1AG1_MOUSE (1)
A1AT1_MOUSE (1)
A1AT2_MOUSE (1)
A1AT4_MOUSE (1)
A2AP_MOUSE (1)
A2RT81_MOUSE (1)
AACS_MOUSE (1)
AAKG1_MOUSE (1)
AATC_MOUSE (1)
AATM_MOUSE (1)
ABCD3_MOUSE (1)
ABCE1_MOUSE (1)
ABCF1_MOUSE (1)

CHEBI ID

CHEBI:16335 (6)
CHEBI:7916 (6)
CHEBI:15891 (6)
CHEBI:16919 (6)
CHEBI:30769 (6)
CHEBI:49033 (5)
CHEBI:16040 (5)
CHEBI:16708 (5)
CHEBI:16750 (5)
CHEBI:16610 (5)
CHEBI:30746 (5)
CHEBI:17821 (5)
CHEBI:17154 (5)
CHEBI:17750 (5)
CHEBI:17053 (5)
CHEBI:16015 (5)
CHEBI:15422 (5)
CHEBI:18012 (5)
CHEBI:16737 (5)
CHEBI:27897 (5)
CHEBI:15354 (5)
CHEBI:17368 (5)
CHEBI:40521 (4)
CHEBI:17200 (4)
CHEBI:15611 (4)
CHEBI:16709 (4)
CHEBI:16856 (4)
CHEBI:17126 (4)
CHEBI:22660 (4)
CHEBI:50183 (1)

Metabolite Name

L-Alanine (4)
Taurine (4)
Citric acid (4)
Pyruvic acid (3)
L-Proline (3)
L-Threonine (3)
Adenosine (3)
N-Acetyl-L-phenylalanine (3)
L-Glutamine (3)
L-Serine (3)
Guanosine (3)
Thymidine (3)
Uridine (3)
Creatine (3)
L-Valine (3)
L-Leucine (3)
L-Glutathione oxidized (2)
Adonitol (2)
AICA ribonucleotide (2)
N-Isovalerylglycine (2)
Taurocholic Acid (2)
21-Deoxycortisol (2)
Inosine 5'-monophosphate (2)
L-Glutamic Acid (2)
3-Methylcrotonylglycine (2)
Mevalonolactone (2)
D-Fructose (2)
D-Glucose (2)
Naringenin (2)
4-Nitrophenol (2)

First Public Date

2025 (107)
2026 (79)
2024 (79)
2023 (63)
2014 (40)
2022 (37)
2021 (30)
2020 (25)
2019 (18)
2018 (18)
2017 (16)
2016 (4)
2013 (4)
2015 (3)

Modelling Approach

Computational model (5)
Ordinary differential equation model (5)
Other (1)
Differential equation model (1)

Study status

Completed (3)
Withdrawn (1)
Recruiting (1)

Lab affiliation

1 Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, P.O.Box 263, FI-00029 HUS, Helsinki, Finland 2 Department of Biosciences and Nutrition, Karolinska Institutet, SE-171 76, Stockholm, Sweden. 3 Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. (2)
Crown Bioscience (2)
Daglig leder, PROMEC Institutt for klinisk og molekylær medisin lars.hagen@ntnu.no 73598508 72573342 Laboratoriesenteret, 231.04.008, Øya, Erling Skjalgssons gate 1 (2)
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA (2)
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany (2)
University of Missouri-Columbia (2)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (2)
1 Garvan Institute of Medical Research and The Kinghorn Cancer Centre, 384 Victoria Street Darlinghurst Sydney, NSW, 2010, Australia. 2 St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Australia. (1)
1) Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; 2) Institute for Bioanalysis, University of Applied Science Coburg, Coburg, Germany (1)
1. Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA 2. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA 3. Paediatric Program, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, NSW, AUSTRALIA (1)
1. Translational Immunology Research Program, Transplantation Laboratory, University of Helsinki, Helsinki, Finland. 2. HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland (1)
Animal Cell Technology Unit, iBET - Instituto de Biologia Experimental e Tecnológica (1)
Assistant Professor, Evolutionary Venomics Lab, Center for Ecological Sciences, Indian Institute of Science, Bangalore, India (1)
Biological Mass Spectrometry Lab Department of Translational Medicine (DiMeT) Center for Translational Research on Autoimmune & Allergic Diseases - CAAD University of Piemonte Orientale Corso Trieste 15/A, 28100, Novara, Italy (1)
Biomedical Research Institute, Foundation for Research and Technology-Hellas, University Campus, 45110 Ioannina, Greece (1)
Cancer Signalling Research Group, School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA. (1)
Center for Research Innovation and Bioinformatics, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand (1)
Chair of Physiological Genomics, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Germany (1)
Chemistry Department, The Scripps Research Institute, La Jolla, California, USA (1)
Clinic and Polyclinic for Pediatric and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany (1)
Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases IRCCS “L. Spallanzani”, Rome, Italy. (1)
Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute of infectious diseases IRCCS Lazzaro Spallanzani, Rome (1)
Department of Human Structure and Repair, Laboratory of Experimental Cancer Research, Ghent University, Belgium3. Cancer Research Institute Ghent (CRIG), Ghent University, Belgium (1)
Department of Molecular Medicine The Skaggs Institute for Chemical Biology The Scripps Research Institute USA (1)
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA (1)
Department of Neuropathology, Medical Research institute and Center for Brain Integration Research, Tokyo Medical and Dental University (1)
Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna (1)
Department of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany (1)
Department of Radiation Medicine, James M. Slater, MD Proton Treatment & Research Center, Loma Linda University Health, Loma Linda, CA 92350, USA (1)
Department of Translational Medicine (DiMeT), Center for Translational Research on Autoimmune & Allergic Diseases - CAAD, University of Piemonte Orientale, Corso Trieste 15/A, 28100, Novara, Italy (1)

Keyword

Colorectal (2)
Endoscopic (1)
Outpatient (1)
Cabometyx (1)
Electroporation (1)
PIFA (1)
Inoperable (1)
HER2 CAR-T (1)
Efficiency (1)
Refractory and relapsed cancer (1)
Tremelimumab (1)
Cabozantinib (1)
Safety (1)
Esophageal (1)
FOLFOX (1)
Bleomycin (1)
Opdivo (1)
Indomethacin (1)
Durvalumab (1)
Metastatic colorectal cancer (1)
Nivolumab (1)
Immunotherapy (1)

IsPrivate

False (12)

Submitter Keywords

Ersilia (5)
Machine Learning Model (5)
TransQST (1)
Not Peer Reviewed (1)

Classification

bacteria (1)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (69)
RNA-seq of coding RNA (21)
Interventional (5)
Animal - One-color microarray (4)
Comparative genomic hybridization by array (4)
Proteomic profiling by array (3)
Methylation profiling by high throughput sequencing (2)
Unknown experiment type (1)
Human - Methylation microarray (1)
ChIP-chip by tiling array (1)
Human - One-color microarray (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
ChIP-seq (1)
Methylation profiling by array (1)
RNA-seq of coding RNA from single cells (1)

Release Date

2022 (2902)
2021 (2732)
2025 (2726)
2023 (2717)
2024 (2212)
2020 (1991)
2019 (1454)
2018 (1228)
2017 (1055)
2016 (994)
2015 (760)
2014 (584)
2026 (420)
2013 (409)
2012 (285)
2011 (203)
2010 (146)
2009 (97)
2008 (54)
2007 (25)
2006 (22)
2005 (7)
2003 (7)
2004 (6)
2001 (4)
1998 (3)
2002 (2)
1999 (2)
2000 (1)
1997 (1)

Location

Ireland (1)
Denmark (1)
China (1)
Netherlands (1)
United States (1)
Switzerland (1)
France (1)

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Glycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes

Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...

2026-02-06 | MTBLS11411 | MetaboLights

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...

2023-05-26 | MTBLS7533 | MetaboLights

New preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry.

Current diagnostic methods for prion diseases in vivo only work in late stages of the disease when neurodegeneration is very advanced and irreversible. Therefore, the search for biomarkers that can detect the disease before the onset of clinical symptoms is necessary. For this purpose, high-throughp...

ORGANISM(S): Ovis aries

2025-04-23 | PXD050656 | Pride

Discover preclinical biomarkers of hepatotoxicity: Acetaminophen and Carbon tetrachloride

Preclinical biomarkers useful for identification of idiosyncratic drugs have not been identified. It is hypothesized that patterns of transcript expression for the hepatotoxicants, including classical and idiosyncratic hepatotoxicants, are similar and the patterns differ from those of non-hepatotox...

ORGANISM(S): Rattus norvegicus

2012-03-15 | E-GEOD-32891 | biostudies-arrayexpress

Preclinical dosimetry models and the prediction of clinical doses of novel positron emission tomography radiotracers.

Not available

S-EPMC7525662 | biostudies-literature

Construction and application of service quality evaluation system in the preclinical research on cardiovascular implant devices.

Not available

S-EPMC6396521 | biostudies-literature

Patient engagement in preclinical laboratory research: A scoping review.

Not available

S-EPMC8318845 | biostudies-literature

The Relationship between Risk of Bias Criteria, Research Outcomes, and Study Sponsorship in a Cohort of Preclinical Thiazolidinedione Animal Studies: A Meta-Analysis.