Sort   by:  
 Page size 
MetabolomicsGlycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes
Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...
2026-02-06 | MTBLS11411 | MetaboLights
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
ProteomicsSPIO corona - Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles
Identification of corona proteins in serum and plasma of healthy donors
ORGANISM(S): Homo sapiens (Human) 
2019-01-14 | PXD011781 | Pride
Spio Plasma Serum Nanoparticles 
TranscriptomicsSGEV_LRS
Comparison of genomic expression profiles in the mesenteric lymph nodes of naturally scrapie infected (clinical and preclinical stages) and control sheep. Expression profiles comparison of 7 clinical and 4 preclinical naturally scrapie infected sheep and 6 controls.
ORGANISM(S): Ovis aries 
2013-10-29 | E-MTAB-1346 | biostudies-arrayexpress
ProteomicsNew preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry.
Current diagnostic methods for prion diseases in vivo only work in late stages of the disease when neurodegeneration is very advanced and irreversible. Therefore, the search for biomarkers that can detect the disease before the onset of clinical symptoms is necessary. For this purpose, high-throughp...
ORGANISM(S): Ovis aries 
2025-04-23 | PXD050656 | Pride
Cerebrospinal fluid Swath Mass spectrometry Neurodegenerative diseases Diagnosis Biomarkers. Prion Scrapie Preclinical 
TranscriptomicsThe novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models
we report characterized the preclinical activity of a new member of this class, the ST1926-derivative ST5589, in lymphomas GEP analysis of 2 lymphoma cell lines with and without treatment
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-66455 | biostudies-arrayexpress
TranscriptomicsSPGEV
Comparison of genomic expression profiles in the medulla oblongata of 4 preclinical naturally scrapie infected sheep and 6 controls.. The experiment consisted of the comparison of gene expression profiles in the medulla oblongata of preclinical scrapie and control sheep using oligoDNA CVI-Agilent c...
ORGANISM(S): Ovis aries 
2012-11-14 | E-MTAB-866 | biostudies-arrayexpress
TranscriptomicsGene expression profile of preclinical arthritis and its modulation by antigen-induced tolerance
During the course of adjuvant arthritis, maximal changes in gene expression were observed at the incubation phase. A major group of genes affected was related to immune activity. Tolerance induction by mycobacterial heat-shock protein 65 (Bhsp65), the disease-related antigen, caused upregulation of ...
ORGANISM(S): Rattus norvegicus 
2011-11-16 | E-GEOD-31314 | biostudies-arrayexpress
UnknownPreclinical dosimetry models and the prediction of clinical doses of novel positron emission tomography radiotracers.
Not available
S-EPMC7525662 | biostudies-literature
GenomicsGut microbiome alterations in preclinical Alzheimer’s disease Running title: Microbiome alterations in preclinical AD
Gut microbiome alterations in preclinical Alzheimer’s disease Running title: Microbiome alterations in preclinical AD
PRJEB50447 | ENA
Sort   by:  
 Page size