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MetabolomicsGlycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes
Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...
2026-02-06 | MTBLS11411 | MetaboLights
MetabolomicsCHOICE clinical weight loss study
Not available
ORGANISM(S): Homo sapiens;Rattus norvegicus 
ST000661 | MetabolomicsWorkbench
MetabolomicsEffects of nicotine on SH-SY5Y cells: an NMR-based metabolomic study

Nicotine is a naturally occurring alkaloid primarily found in Nicotiana tabacum. This phytochemical is well known for its addictive properties, and its consumption—particularly through tobacco smoking—is strongly associated with an increased risk of malignancies, metabolic dysfunctions, and cardi...

2026-06-26 | MTBLS12848 | MetaboLights
TranscriptomicsSGEV_LRS
Comparison of genomic expression profiles in the mesenteric lymph nodes of naturally scrapie infected (clinical and preclinical stages) and control sheep. Expression profiles comparison of 7 clinical and 4 preclinical naturally scrapie infected sheep and 6 controls.
ORGANISM(S): Ovis aries 
2013-10-29 | E-MTAB-1346 | biostudies-arrayexpress
ProteomicsNew preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry.
Current diagnostic methods for prion diseases in vivo only work in late stages of the disease when neurodegeneration is very advanced and irreversible. Therefore, the search for biomarkers that can detect the disease before the onset of clinical symptoms is necessary. For this purpose, high-throughp...
ORGANISM(S): Ovis aries 
2025-04-23 | PXD050656 | Pride
Cerebrospinal fluid Swath Mass spectrometry Neurodegenerative diseases Diagnosis Biomarkers. Prion Scrapie Preclinical 
TranscriptomicsGene expression profile of preclinical arthritis and its modulation by antigen-induced tolerance
During the course of adjuvant arthritis, maximal changes in gene expression were observed at the incubation phase. A major group of genes affected was related to immune activity. Tolerance induction by mycobacterial heat-shock protein 65 (Bhsp65), the disease-related antigen, caused upregulation of ...
ORGANISM(S): Rattus norvegicus 
2011-11-16 | E-GEOD-31314 | biostudies-arrayexpress
TranscriptomicsDiscover preclinical biomarkers of hepatotoxicity: Acetaminophen and Carbon tetrachloride
Preclinical biomarkers useful for identification of idiosyncratic drugs have not been identified. It is hypothesized that patterns of transcript expression for the hepatotoxicants, including classical and idiosyncratic hepatotoxicants, are similar and the patterns differ from those of non-hepatotox...
ORGANISM(S): Rattus norvegicus 
2012-03-15 | E-GEOD-32891 | biostudies-arrayexpress
TranscriptomicsSPGEV
Comparison of genomic expression profiles in the medulla oblongata of 4 preclinical naturally scrapie infected sheep and 6 controls.. The experiment consisted of the comparison of gene expression profiles in the medulla oblongata of preclinical scrapie and control sheep using oligoDNA CVI-Agilent c...
ORGANISM(S): Ovis aries 
2012-11-14 | E-MTAB-866 | biostudies-arrayexpress
TranscriptomicsMouse alveolar rhabdomyosarcoma and wild-type skeletal muscle
The highly aggressive muscle cancer alveolar rhabdomyosarcoma (ARMS) is one of the most common soft tissue sarcoma of childhood, yet the outcome for unresectable and metastatic disease is dismal and unchanged for nearly 3 decades. To better understand the pathogenesis of this disease and to facilita...
ORGANISM(S): Mus musculus 
2009-08-27 | E-GEOD-15489 | biostudies-arrayexpress
GenomicsHSP90 specific nIR probe identifies aggressive prostate cancers: a translational study from preclinical models to a human pilot study
HSP90 specific nIR probe identifies aggressive prostate cancers: a translational study from preclinical models to a human pilot study
PRJNA692222 | ENA
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