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TranscriptomicsCellular senescence reprograms human NK cells to promote vascular remodeling
Natural killer (NK) cells are lymphocytes that participate in immune responses through their cytotoxic activity and secretion of cytokines and chemokines. They can be activated by interaction with ligands on target cells or by soluble mediators such as cytokines. In addition, soluble HLA-G, a major ...
ORGANISM(S): Homo sapiens 
2012-12-03 | E-GEOD-35330 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human NK cells sorted into CD56dim and CD56bright NK cell subpopulations
Human NK cells were sorted into CD56dim and CD56bright NK cell subpopulations. In order to define characteristics of both populations gene profiling was performed using Affymetrix arrays U133a and U133B.
ORGANISM(S): Homo sapiens 
2006-05-31 | E-MEXP-380 | biostudies-arrayexpress
TranscriptomicsRunx3 function in splenic NK cells (IL-2 or IL-15)
NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent. To identify Runx3 responsive genes, NK cells were isolated from spleen of WT and Runx3-/- mic...
ORGANISM(S): Mus musculus 
2013-11-18 | E-GEOD-50122 | biostudies-arrayexpress
ProteomicsProteomic profiling of subsets of human primary NK cell-derived extracellular vesicles by LC-MS/MS
In this study we have compared the proteomic profile of subsets of extracellular vesicles (EVs) prepared from primary human NK cells cultured for 48hrs in serum-free conditions supplemented with 10 ng/ml human recombinant IL-12, IL-15, and IL-18. The aim was to isolate and define an EV subset with c...
ORGANISM(S): Homo sapiens (Human) 
2022-09-09 | PXD035977 | Pride
Il-18 Nk cells Dg-uc Il-12 Il-15 Evs Lc-ms/ms 
ProteomicsNK-cell derived extracellular vesicles LC-MS/MS
In this study we have compared the proteomic profile of extracellular vesicles (EVs) prepared from primary, human NK cells or the human NK cell lines NK-92 and KHYG-1 cultured for 48hrs in serum-free conditions. EVs were harvested from cells either under resting conditions (culture in IL-15) or upon...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027284 | Pride
Nk-92 Nk cells Il-18 Cd16 Il-12 Khyg-1 Il-15 Lc-ms/ms 
TranscriptomicsTranscriptomic profiling of human primary NK cells treated with cortisol and/or co-cultured with K562 target cells
Human primary NK cells were isolated from peripheral blood mononuclear cells (PBMCs) and cultured under two conditions: with or without cortisol (1 µM). In parallel, primary NK cells were co-cultured with K562 target cells for 6 hours in the presence or absence of cortisol (1 µM) to assess the impac...
ORGANISM(S): Homo sapiens 
2025-12-18 | E-MTAB-16365 | biostudies-arrayexpress
GenomicsProliferation conditions promote intrinsic changes in NK Cells for an IL-10 response
Constitutively found at high frequencies, the role for NK cell proliferation remains unclear. Here, a shift in NK cell function from predominantly producing interferon-? (IFN-?), a cytokine with proinflammatory and antimicrobial functions, to producing the immunoregulatory cytokine IL-10, is defined...
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-55834 | biostudies-arrayexpress
TranscriptomicsIFN alpha-induced gene expression in human NK cells
NK cells are believed to contribute to the control of hepatitis C virus infection and pathogenesis of liver disease. Standard treatment of both acute and chronic hepatitis C is based on the administration of interferon alpha, however, the effects of type I interferons on human NK cells have not been...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-15743 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of FACS-sorted ex vivo NK cells from control (Cre neg, GFPNK/NK), STAT5BNK/NK, N642HNK/NK and diseased N642HNK/NK mice
Somatic STAT5B gain-of-function mutations have been frequently found in patients with T- and NK-cell neoplasms. STAT5BN642H represents the most frequently occuring STAT5B mutation. To investigate the molecular mechanism of STAT5BN642H-driven NK-cell leukemia, we performed RNA-Seq of liver derived FA...
ORGANISM(S): Mus musculus 
2024-05-01 | E-MTAB-13797 | biostudies-arrayexpress
TranscriptomicsNext-generation sequencing identifies the natural killer cell microRNA transcriptome
Natural killer (NK) cells are innate lymphocytes important for early host defense against infectious pathogens and surveillance against malignant transformation. Resting murine NK cells regulate the translation of effector molecule mRNAs (e.g. granzyme B, GzmB) through unclear molecular mechanisms....
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-21003 | biostudies-arrayexpress
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