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MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15616 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse dendritic subsets in vivo
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6259 | biostudies-arrayexpress
TranscriptomicsImproved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
Attenuated poxviruses are safe and capable to express foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune respon...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-26239 | biostudies-arrayexpress
ProteomicsMass spectrometry of HLA-I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation
HLA class I molecules reflect the health state of cells to cytotoxic T-cells by presenting a repertoire of endogenously derived peptides. However, the extent to which the proteome shapes the peptidome is still largely unknown. Here we present a high-throughput mass-spectrometry-based workflow that a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-29 | MSV000079539 | MassIVE
TranscriptomicsTranscription profiling of human CD4+ T cells induced by HIV-1 gp120/V3 loop peptides, time series
Comparative changes of gene expression in human primary CD4+ T cells induced by HIV-1 gp120/V3 loop synthetic peptides, during antigen presentation
ORGANISM(S): Homo sapiens 
2008-09-01 | E-MEXP-1586 | biostudies-arrayexpress
GenomicsHippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity
Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity
PRJNA1063716 | ENA
ProteomicsComposition and processing activity of a semi-recombinant holo U7 snRNP
In animal cells, replication-dependent histone pre-mRNAs are cleaved at the 3’ end by U7 snRNP consisting of two core components: a ~60-nucleotide U7 snRNA and a ring of seven proteins, with Lsm10 and Lsm11 replacing the spliceosomal SmD1 and SmD2. Lsm11 interacts with FLASH and together they recrui...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-25 | PXD014164 | Pride
Sm proteins U7 snrnp Cpsf73 Lsm11 Flash Histone pre-mrna 3’ end processing 
ProteomicsHLA-DP(84Gly) constitutively presents endogenous peptides generated by the class I antigen processing pathway
Classical antigen processing/presentation mechanisms lead to the presentation of antigenic peptides derived from endogenous and exogenous sources for MHC class I and class II molecules, respectively. We show here that, unlike other class II, prevalent HLA-DP molecules whose chains encode Gly84 (DP8...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080228 | MassIVE
ProteomicsProteomic analysis of regulated dendritic cell endosomes reveals dynamic adaptation to antigen uptake and cross-presentation
MHC class I cross-presentation involves final proteolytic peptide processing by the endosomal insulin-regulated aminopeptidase (IRAP). Reasoning that analysis of the IRAP proximal proteome may inform about dynamic remodeling of a key cross-presentation compartment during antigen uptake, we developed...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD067092 | Pride
Endosome Insulin-regulated aminopeptidase Proximity biotinylation Cross-presentation Dendritic cell 
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