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TranscriptomicsTranscription profiling of wild type and A-C/EBP transgenic mouse embryonic fibroblasts during adipogenesis to identify C/ebp alpha target genes
This experiment was designed to identify C/ebp alpha target genes during the process of adipogenesis by means of comparison of differentiating (wild-type) cells to a perturbation model (transgenic cells). For this, gene expression profiling during adipogenesis of mouse embryonic fibroblasts (MEFs) ...
ORGANISM(S): Mus musculus 
2009-07-02 | E-MARS-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of six tissues from ATGL knock-out versus wild type mice
Gene expression profiling in 6 tissues (white adipose tissue (WAT), brown adipose tissue (BAT), cardiac muscle (CM), liver (LIV), kidney (KID), skeletal muscle (SM)) from ATGL(-/-) mice versus wildtype (ATGL+/+) mice.
ORGANISM(S): Mus musculus 
2008-02-03 | E-MARS-8 | biostudies-arrayexpress
ProteomicsFasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism
Cancer cells voraciously consume nutrients to support their growth, exposing a metabolic vulnerability that can be therapeutically exploited. Here we show in hepatocellular carcinoma (HCC) cells, xenografts, and in patient-derived HCC organoids that fasting can synergistically sensitise resistant HC...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-16 | PXD022723 | Pride
Xenografts Starvation Hcc Sorafenib Tp53 Hepg2 
ProteomicsProximity-biotinylation (BioID) to dissect cytoplasmic p53 signaling networks under nutrient stress
p53 signaling is a major response mechanism to cellular stresses through cytoplasmic or nuclear action. While p53 protein levels have been shown to increase upon nutrient stresses such as starvation, the exact signaling cascade in this context remains elusive. Here, we use proximity biotinylation (B...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD027734 | Pride
Nutrient stress Starvation P53 signaling Bioid Interactome 
TranscriptomicsTranscription profiling of dfferentiation of human bone marrow derived hMSC with beta-glycerphosphate, ascorbicacidphosphate and dexamethasone for 21 days;evaluated time points d4, d7, d14 and d21 after induction
Differentiation of bone marrow derived hMSC with beta-glycerphosphate, ascorbicacidphosphate and dexamethasone for 21 days;evaluated time points d4, d7, d14 and d21 after induction; reference d-1 (one day before induction; preconfluent 70-80%)
ORGANISM(S): Homo sapiens 
2007-06-09 | E-MARS-3 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse white adipose tissue and brown adipose tissue from Bscl2 knock-out mice and their wild-type control mice
Experiments were designed to compare white adipose tissue (WAT) or brown adipose tissue (BAT) -in male and female mice- between Bscl2 knock-out mice and their wild-type control mice. RNA was pooled to obtain 2x 8µg per tissue source and subjected to dye-swap hybridization.
ORGANISM(S): Mus musculus 
2010-06-09 | E-MARS-18 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BM-MSC expanded from p2 until p10 and monitored by FACS, proliferation kinetics and differentiation ability
hBM-MSC were expanded from p2 until p10 and monitored by FACS, proliferation kinetics and differentiation ability;µA analysis were performed p2/p5 (n=10)and p5/p10 (n=5) to examine if the genetic background of hBM-MSC is changeing during their high-grade expansion;
ORGANISM(S): Homo sapiens 
2007-06-09 | E-MARS-6 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BM-MSC expanded from p2 until p10 and monitored by FACS, proliferation kinetics and differentiation ability
hBM-MSC were expanded from p2 until p10 and monitored by FACS, proliferation kinetics and differentiation ability;µA analysis were performed p2/p5 (n=10)and p5/p10 (n=5) to examine if the genetic background of hBM-MSC is changeing during their high-grade expansion;
ORGANISM(S): Homo sapiens 
2007-06-09 | E-MARS-5 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of in vitro / in vivo osteoblast comparison-Comparison of in vivo and in vitro developed human osteoblasts
Comparison of the genetic profile of hBM-MSC differentiated in vitro into osteoblasts with in vivo developed osteoblasts derived from hip bone.
ORGANISM(S): Homo sapiens 
2007-06-09 | E-MARS-4 | biostudies-arrayexpress
TranscriptomicsEffect of Nur77 on gene expression in white adipose tissue of fasted mice.
The aim was to study the effects of Nur77 on the white adipose tissue transcriptome after fasting. For this purpose we performed gene expression profiling of white adipose tissue from Nur77-/- mice and wildtype (Nur77+/+) littermates submitted to prolonged fasting using microarray analysis on >27k e...
ORGANISM(S): Mus musculus 
2012-11-09 | E-MEXP-3771 | biostudies-arrayexpress
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