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MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
MetabolomicsTargeted Metabolomics Study: The Association Between Ovarian Function and Amino Acid Level Changes in Breast Cancer Patients Before and After Chemotherapy.

Cyclophosphamide (CTX) is a primary medicine for curing breast cancer which often caused premature ovarian insufficiency (POI). Our recent publication reveals that CTX induced POI by promoting the expression of SLC1A4, a transporter of serine efflux, in ovarian granulosa cells (GCs). Here, we rep...

2025-12-23 | MTBLS13561 | MetaboLights
ModelsSheikIsmail_Amino Acid Insertions in the Hinge Region of HIV Protease Affect Enzyme Kinetics, Conformational Stability and Dynamics
The models correspond to the WT and mutant protease described in the article.
2025-10-24 | MODEL2207110001 | BioModels
ProteomicsMolecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model
LC-MS/MS of Prss37 WT and KO mice male reproductive tract. Title: Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model Authors: Courtney Sutton1,2, Kaori Nozawa1,2, Katarzyna Kent1,2, Alexander Saltzman3, Mei Leng3, Sureshbabu Na...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-07 | MSV000091662 | MassIVE
ProteomicsDirect in-gel profiling of protease specificity (DIPPS)
Determination of protease specificity is of crucial importance for understanding protease function. We have developed the first gel-based label-free proteomic approach (DIPPS) that enables quick and reliable determination of protease cleavage specificities under large variety of experimental conditi...
ORGANISM(S): Aeropyrum pernix Homo sapiens (Human) 
2017-07-06 | PXD004218 | Pride
Specificity profiling Protease Legumain Cathepsin Degradomics 
GenomicsMalt1 protease is critical in maintaining function of Treg cells and may be a therapeutic target for anti-tumor immunity
Malt1 protease is critical in maintaining function of Treg cells and may be a therapeutic target for anti-tumor immunity
PRJNA510753 | ENA
TranscriptomicsTMPRSS2 Influences Prostate Cancer Metastasis
TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion ...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-58822 | biostudies-arrayexpress
ProteomicsRhomboid mediates membrane protein quality control as an intramembrane protease and adaptor of AAA protease.
Magnesium homeostasis is essential for life and depends on magnesium transporters whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom but their functions are largely elusive. Using proteomics we find that Bacillus subtili...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-01-09 | PXD014578 | Pride
Transporter Er associated degradation Intramembrane protease Manganese Tripletof 5600 Magnesium Bacillus subtilis Lipid membrane Gelc-ms/ms Rhomboid protease Proteostasis Zinc 
GenomicsSite-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
PRJNA484767 | ENA
GenomicsThe secreted protease Adamts18 links mammary epithelial hormone action to extracellular matrix changes and stem cell niche function
The secreted protease Adamts18 links mammary epithelial hormone action to extracellular matrix changes and stem cell niche function
PRJNA607942 | ENA
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