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MetabolomicsLow-Protein Diet Enhances Anti-Tumor Immunity in Pancreatic Cancer through Microbiota-Derived Uridine Diphosphate-Galactose
Low-protein diets (LPD) have been linked to improved metabolic health, but their role in pancreatic ductal adenocarcinoma (PDAC) immunotherapy remains unclear. Here we show that an LPD suppresses PDAC progression in male mice by remodeling the gut microbiota and activating anti-tumor immunity. LPD p...
2026-07-09 | MTBLS14989 | MetaboLights
ProteomicsMYC as a Key Regulator of Protein Synthesis: Characterization of Downstream Targets in Multiple Myeloma
Multiple myeloma (MM) is a malignant plasma cell disorder and frequently characterized by the 16 dysregulation of the MYC oncogene, which is associated with poor prognosis and disease progression. While MYC's involvement in transcriptional regulation is well-established, the functional role of MYC t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-15 | MSV000092169 | MassIVE
ProteomicsYeast glutamine tRNA synthetase doxycycline shut-off
During protein synthesis, charged tRNAs deliver amino acids to translating ribosomes, and are then re-charged by tRNA synthetases (aaRS). In humans, mutant aaRS cause a diversity of neurological disorders, but their molecular aetiologies are incompletely characterised. To understand system responses...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-12 | PXD017140 | Pride
Saccharomyces cerevisiae Silac Translation Trna synthetase depletion 
ProteomicsThe Isotopic Depletion Increases the Spatial Resolution of FPOP Top-Down Analysis.
Protein radical labeling offers an alternative analytical method for probing protein structure or protein interaction with other bio-molecules. Since the Fast Photochemical Oxidation of Proteins has already shown its essential role in studying biomolecular as-semblies and it was successfully adopted...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044447 | Pride
Protein isotope depletion Ire Fast photochemical oxidation of proteins Mass spectrometry Insulin response element Top-down Foxo4 Electron-capture dissociation Multicasi. 
UnknownDetermining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry.
Not available
S-EPMC10161212 | biostudies-literature
ProteomicsRapid factor depletion highlights intricacies of nucleoplasmic RNA degradation
Turnover of nucleoplasmic transcripts by the multi-subunit RNA exosome is mediated by two adaptors; the Nuclear EXosome Targeting (NEXT) complex and the Poly(A) tail eXosome Targeting (PAXT) connection. Functional analyses of NEXT and PAXT have largely been based on long-term factor depletion strate...
ORGANISM(S): Homo sapiens (Human) 
2021-12-23 | PXD026774 | Pride
Rna exosome Tmtpro Next Paxt Degron tag 
ProteomicsReprogramming neuroblastoma by diet-enhanced polyamine depletion
Cancer growth is fueled by nutrients obtained from circulation and local biosynthesis. Isolating and exploiting tumoral nutrient dependencies to potentiate current anti-cancer therapies is undergoing active research. We used unbiased metabolomics on patient samples and identified reprogramming of th...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-24 | PXD047396 | Pride
Neuroblastoma Th-mycn Difluoromethylornithine 
UnknownNitrogen isotope signature evidences ammonium deprotonation as a common transport mechanism for the AMT-Mep-Rh protein superfamily.
Not available
S-EPMC6135547 | biostudies-literature
ProteomicsLocal depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model
Successfully replacing damaged cartilage with tissue-engineered constructs requires integration with the host tissue and could benefit from leveraging the native tissue's intrinsic healing capacity; however, efforts are limited by a poor understanding of how cartilage repairs minor defects. Here, we...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-07-18 | PXD035246 | Pride
Proteoglycan depletion Cartilage repair Catabolic enzyme Tissue engineering 
UnknownPartial Isotope Profiles Are Sufficient for Protein Turnover Analysis Using Closed-Form Equations of Mass Isotopomer Dynamics.
Not available
S-EPMC8880304 | biostudies-literature
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