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ProteomicsPrecisely measured protein lifetimes in the mouse
The turnover of brain proteins is critical for organism survival, and its perturbations are strongly linked to pathology. Nevertheless, precise protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically-labeled amino acids, followed...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-15 | PXD010859 | Pride
Neuron Ellps Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes Glia 
ProteomicsCombined measurements of proteome and cell turnover reveal the influences of tissue context and pathological aging on protein and organelle lifetimes
The lifespans of proteins can range from moments to years within mammalian tissues. Protein lifespan is relevant to organismal aging, as long-lived proteins can accrue damage over time. It is unclear how protein lifetime is shaped by tissue context, where both cell division and proteolytic degradati...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-21 | PXD033649 | Pride
Proteostasis Mouse Protein turnover Silam Lc-ms/ms 
ProteomicsPrecisely measured protein lifetimes in the brain of aged mice
Aging, which is associated with protein homeostasis defects, is one of the most prominent risk factors for neurodegenerative disorders and the regulation of protein homeostasis is essential for brain health. While several studies have addressed changes in protein abundance due to aging, little is kn...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD023994 | Pride
Synapse Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes 
UnknownImproved Fluorescent Protein Contrast and Discrimination by Optically Controlling Dark State Lifetimes.
Not available
S-EPMC5313373 | biostudies-literature
UnknownProtein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration.
Not available
S-EPMC9122331 | biostudies-literature
UnknownThe codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.
Not available
S-EPMC6237891 | biostudies-literature
UnknownTurnover and replication analysis by isotope labeling (TRAIL) reveals the influence of tissue context on protein and organelle lifetimes.
Not available
S-EPMC10090950 | biostudies-literature
UnknownPrecisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.
Not available
S-EPMC6185916 | biostudies-literature
ProteomicsCardiolipin prolongs the lifetimes of respiratory proteins in Drosophila flight muscle
To measure concurrently the lifetimes of proteins and lipids, we incubated fruit flies with stable isotope-labeled precursors (13C615N2-lysine or 13C6-glucose) and determined the relative abundance of heavy isotopomers in protein and lipid species by mass spectrometry. We restricted our analysis to ...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2023-05-15 | MSV000091946 | MassIVE
UnknownFluorescent protein lifetimes report densities and phases of nuclear condensates during embryonic stem-cell differentiation.
Not available
S-EPMC10423231 | biostudies-literature
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