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ProteomicsProteomics analysis of guinea pig retina at the early stage of myopia
This is a combined SWATH database of early myopic guinea pig retina. The retinal tissues were divided into lens induced myopia 4 days group (4-day LIM) and control group; 5 individual animals (10 retinas) were included. The potential biomarkers and underlying biochemical pathways during early myopia...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-05-13 | PXD025003 | Pride
Proteomics guinea pig retina myopia 
ProteomicsProteomic study of the retina of guinea pigs with form-deprivation myopia
Myopia has become the major cause of visual impairment worldwide. However, its retina-related pathogenesis remains unclear. In recent years, proteomics has become a high-throughput tool to explain biological mechanisms. In this study, we examined the retinas of guinea pigs with form deprivation myop...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2023-07-12 | PXD043226 | Pride
Guinea pig Proteome Retina 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067757 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067446 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067756 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
ProteomicsLactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia
Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine lactylation of proteins plays a key role in regu...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2024-10-17 | PXD046495 | Pride
Lysine lactylation Form-deprivation myopia Lactate Aerobic glycolysis Retina 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. The retinal–choroid–sclera (RCS) signalling cascade is crucial in regulating eye growth and is influenced by visually induced signalling. Understanding the molecular mechanisms underlying this cascade is vital to identify therapeutic targets for myop...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD052167 | Pride
Phosphoproteomic Proteomic Form-deprivation myopia (fdm)  retina-choroid-sclera (rcs) 
ProteomicsWidespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs
Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine acetylation of proteins plays a key role in regu...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2023-07-12 | PXD043196 | Pride
Form-deprivation myopia  retina  lysine acetylation  glycolysis 
ProteomicsTMT-Based Quantitative Proteomic Profiling of Retina, Choroid, and Sclera in Albino and Pigmented Guinea Pigs to Investigate Myopia Susceptibility and Pathogenesis
Myopia development and susceptibility vary across pigmentation backgrounds and ocular tissues, yet the underlying molecular mechanisms remain unclear. In this study, retina, choroid, and sclera were collected from albino and pigmented guinea pigs subjected to spontaneously developed hyperopia and my...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2026-08-24 | PXD069847 | Pride
Guinea pig Myopia Proteomics Sclera Choroid Retina 
ProteomicsGuinea pig myopia model ocular posterior pole
Proteomic analyses of the ocular posterior pole tissues at 6 weeks after induction of form-deprived myopia and lens-induced myopia models in guinea pigs.
ORGANISM(S): Cavia Porcellus 
2022-11-01 | PXD037872 |
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