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GenomicsSexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
PRJNA1134075 | ENA
UnknownEnhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat.
Not available
S-EPMC9479128 | biostudies-literature
TranscriptomicsSexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
Osteoarthritis (OA) is a disease with sex-dependent prevalence and severity in both human and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (AC...
ORGANISM(S): Mus musculus 
2024-07-17 | GSE271903 | GEO
UnknownAnti-Inflammatory Therapeutic Approaches to Prevent or Delay Post-Traumatic Osteoarthritis (PTOA) of the Knee Joint with a Focus on Sustained Delivery Approaches.
Not available
S-EPMC8347094 | biostudies-literature
ProteomicsTissue Catabolism and Donor-Specific Dexamethasone Response in a Human Osteochondral Model of Post-Traumatic Osteoarthritis
We present an ex vivo human osteochondral model of PTOA to investigate disease effects on catabolism and cellular homeostasis in a multi-tissue system and discover biomarkers for disease progression and drug efficacy.
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032213 | Pride
Proteomics Ptoa model Osteochondral Explant culture Dexamethasone 
UnknownSynoviocyte-chondrocyte triculture model for early-stage PTOA: fibronectin fragment-induced catabolic effects <i>in vitro</i> and <i>in vivo</i>.
Not available
S-EPMC12711863 | biostudies-literature
GenomicsCharacterization of extracellular vesicles in plasma and synovial fluid of horses with naturally occurring post-traumatic osteoarthritis: An exploratory study to identify transcriptomic profiles.
Objective: The objective of this study was to characterize extracellular vesicles (EVs) in plasma and synovial fluid obtained from horses with and without naturally occurring post-traumatic osteoarthritis (PTOA). Animals (Samples): EVs were isolated from plasma and synovial fluid from horses with (n...
ORGANISM(S): Equus caballus 
2024-06-01 | GSE256340 | GEO
TranscriptomicsComparative Transcriptomics of STR/ort, C57BL/6 and MRL/MpJ Knee Joints
Injuries to the anterior cruciate ligament (ACL) often result in post-traumatic osteoarthritis (PTOA). PTOA accounts for ~12% of all osteoarthritis (OA) cases, yet the mechanisms contributing to OA after joint injury are not well understood. To better understand the molecular mechanisms behind PTOA ...
ORGANISM(S): Mus musculus 
2018-11-28 | GSE112641 | GEO
TranscriptomicsCSF1-R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury I
Knee osteoarthritis contributes substantially to worldwide disability. Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury, such as ligament rupture, and there is increasing evidence suggesting a key role for inflammation in the etiology of PTOA and associated functional defici...
ORGANISM(S): Mus musculus 
2025-06-25 | GSE275957 | GEO
TranscriptomicsCSF1-R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury II
Knee osteoarthritis contributes substantially to worldwide disability. Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury, such as ligament rupture, and there is increasing evidence suggesting a key role for inflammation in the etiology of PTOA and associated functional defici...
ORGANISM(S): Mus musculus 
2025-06-25 | GSE275958 | GEO
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