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ProteomicsImmunopeptidomics analysis of mesothelmia cell line
We have analysed a patinet derived mesothelioma cell line by immuniopeptidomics and identified cancer antignes in this line immunopeptidome.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD037845 | Pride
Immunopeptidomics mesothelmia hla proteomics erv 
ProteomicsIFNγ modulates the immunopeptidome of triple negative breast cancer cells by enhancing and diversifying antigen processing and presentation.
Peptide vaccination remains a viable approach to induce T-cell mediated killing of tumours. To identify potential T-cell targets for Triple-Negative Breast Cancer (TNBC) vaccination, we examined the effect of the pro-inflammatory cytokine interferon-γ (IFNγ) on the transcriptome, proteome and immuno...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD023044 | Pride
Hla Breast cancer Immunopeptidomics 
ProteomicsHLA-C*05:01 and HLA-C*07:02 from 721.221 cells
HLA-C expresion varies widely across the different HLA-C alleles. MicroRNA binding can partly explain the differences in HLA-C allele expression however other contributing factors still remain undetermined. Here we use two common HLA-C alleles, HLA-C*05:01 and HLA-C*07:02, to explore differences in ...
ORGANISM(S): Homo sapiens (Human) 
2017-07-03 | PXD006455 | Pride
Human Hla-c Hla class i 
ProteomicsDeep Exploration of the Immunopeptidome of a Pancreatic Cancer Cell Line Panc1: Implications for Clinical Immunopeptidomics and Immunotherapy (DDA datasets)
Pancreatic ductal adenocarcinoma (PDAC), with its devastating prognosis and limited treatment options, necessitates innovative therapeutic strategies. T-cell-based immunotherapy has shown promise for various cancers, including PDAC. Thus, a comprehensive understanding of the HLA-peptidome in PDAC is...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD054360 | Pride
Tumor-associated antigens Hla Variable window zenoswath dia Pancreatic cancer Immunopeptidome Pdac 
ProteomicsDeep Exploration of the Immunopeptidome of a Pancreatic Cancer Cell Line Panc1: Implications for Clinical Immunopeptidomics and Immunotherapy (SWATH-DIA datasets)
Pancreatic ductal adenocarcinoma (PDAC), with its devastating prognosis and limited treatment options, necessitates innovative therapeutic strategies. T-cell-based immunotherapy has shown promise for various cancers, including PDAC. Thus, a comprehensive understanding of the HLA-peptidome in PDAC is...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD054417 | Pride
Tumor-associated antigens Hla Variable window zenoswath dia Pancreatic cancer Immunopeptidome Pdac 
ProteomicsHLA DR1 and DR15 ligands isolated from transgenic mice
Dominant protection from HLA-associated autoimmune disease is conferred by antigen specific regulatory T cells. Susceptibility and protection against human T cell mediated autoimmune diseases, including type I diabetes, multiple sclerosis and Goodpasture’s disease, is associated with particular Huma...
ORGANISM(S): Mus musculus (Mouse) 
2017-05-04 | PXD005935 | Pride
Mouse Dr15 Goodpasture’s disease Dr1 Hla class ii 
ProteomicsAlagebrium chloride therapy acts to preserve beta cell health
Aims/hypothesis AGEs are considered environmental contributors of type 1 diabetes, but the exact role AGEs play early in pathogenesis of the disease, remains unidentified. We aimed to reduce AGEs with the pharmacotherapy alagebrium chloride in MIN6N8 cells and early in life in NOD mice to determine...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-29 | PXD025998 | Pride
Diabetes hla proteomics 
ProteomicsDIA acquisition of the immunopeptidomes of C1R-B*57:01 and C1R-A*02:01 cell lines
Immunopeptidomes are the peptide repertoires bound by the molecules encoded by the major histocompatibility complex (MHC) (human leukocyte antigen (HLA) in humans). These HLA-peptide complexes are presented on the cell surface for immune T cell recognition. Immunopeptidomics utilizes tandem mass spe...
ORGANISM(S): Homo sapiens (Human) 
2023-02-13 | PXD034539 | Pride
Mass spectrometry  immunopeptidomics  dia  software tools benchmark  hla-bound peptides  spectral library 
ProteomicsThe self-peptide repertoire plays a critical role in transplant tolerance induction
While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly-alloreactive CD8+ T cells have not been defined. In this study, we used a combination of genetically-engineered MHC I constructs, mice with a hepatocyt...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-06 | PXD023015 | Pride
Immunopeptidomics Hla Transplantation 
ProteomicsImmunopeptidome of an acute myeloid leukemia cell line THP1
We report the use of complementary peptide antigen enrichment and comprehensive mass spectrometric acquisition strategies to provide in-depth immunopeptidome data for AML cell line THP1
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-09 | MSV000087786 | MassIVE
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