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ProteomicsProfiling of spreading- coupled protein tyrosine phosphorylation
Protein tyrosine phosphorylation is an important mechanism that regulates cytoskeleton reorganization and cell spreading of migratory cells. A number of cytoskeletal proteins are known to be tyrosine phosphorylated (pY) in different cellular processes. However, the profile of pY proteins during diff...
ORGANISM(S): Homo sapiens (Human) 
2016-09-28 | PXD004340 | Pride
Spreading Fibronectin Ecv304 
ProteomicsAutomated Enrichment of Phosphotyrosine Peptides for High-Throughput Proteomics
Phosphotyrosine (pY) enrichment is critical for expanding fundamental and clinical understanding of cellular signaling by mass spectrometry-based proteomics. However, current pY enrichment methods exhibit a high cost per sample and limited reproducibility due to expensive affinity reagents and manua...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD041271 | Pride
Hela Lc-msms Kingfisher Orbitrap eclipse Orbitrap exploris 480 Phosphotyrosine enrichment 
ProteomicsLowering Sample Requirements to Study Tyrosine Kinase Signaling using Phosphoproteomics with the TMT Calibrator Approach
Analysis of tyrosine kinase signaling is critical for the development of targeted cancer therapy. Currently, immunoprecipitation (IP) of phosphotyrosine (pY) peptides prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to profile kinase substrates. A typical protocol requests ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD018952 | Pride
Signaling Tmt Cancer Calibrator Tyrosine phosphorylation 
ProteomicsLowering Sample Requirements to Study Tyrosine Kinase Signaling using Phosphoproteomics with the TMT Calibrator Approach
Analysis of tyrosine kinase signaling is critical for the development of targeted cancer therapy. Currently, immunoprecipitation (IP) of phosphotyrosine (pY) peptides prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to profile kinase substrates. A typical protocol request...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD019764 | Pride
Signaling Phosphotyrosine Label free quantification Lung cancer Lc-ms/ms 
ProteomicsLung_pY profiling - Profiling phospho-tyrosine levels in mosue tumors which were xenografted from pateint lung tumor.
Profiling phospho-tyrosine levels in mosue tumors which were xenografted from pateint lung tumor.
ORGANISM(S): Homo sapiens (Human) 
2018-09-07 | PXD000809 | Pride
Py profiling Lung Ptm Xenograft Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse hemangioendothelioma cell lines EOMA and Py-4-1 models for kaposiform hemangioendotheliomas
Kaposi’s sarcoma (KS) is the most frequently occurring malignant tumor in patients infected with the human immunodeficiency virus. Recent studies have revealed that infection of vascular endothelial cells with Kaposi's sarcoma-associated herpes virus in vitro results in a lymphatic re-programming ...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-8171 | biostudies-arrayexpress
TranscriptomicsComparison of the expression profiles of R20291 strain : a wild type strain, a fliC mutant and a fliC mutant complemented after 14h of growth in PY and a wild type strain and a fliC mutant after 14h of mouse infection in vivo
Transcriptionnal profiling of C. difficile R20291 strain : a wild type strain, a fliC mutant and a fliC mutant complemented after 14h of growth in PY and a wild type strain and a fliC mutant after 14h of mouse infection in Vivo two-conditions experiments, R20291 strain : a wild type strain, a fliC m...
ORGANISM(S): [Clostridium] difficile 
2013-12-31 | E-GEOD-35727 | biostudies-arrayexpress
TranscriptomicsComparison of the expression profiles of R20291 strain : a wild type strain, a fliC mutant and a fliC mutant complemented after 14h of growth in PY and a wild type strain and a fliC mutant after 14h of mouse infection in vivo
Transcriptionnal profiling of C. difficile R20291 strain : a wild type strain, a fliC mutant and a fliC mutant complemented after 14h of growth in PY and a wild type strain and a fliC mutant after 14h of mouse infection in Vivo
ORGANISM(S): Clostridioides difficile 
2013-12-31 | GSE35727 | GEO
ProteomicsMulti-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled at the genome, transcriptome and proteome level by analysis of gene copy number variation, whole exome sequencing, DNA methylation, transcriptome, proteome and phospho(Tyr)-proteome. At the proteo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-24 | PXD016674 | Pride
Human Nsclc Phosphorylation Pdx Tyrosine Proteome 
TranscriptomicsGene Expression Changes in a Tumor Xenograft by a Py-Im Polyamide
Gene regulation by DNA binding small molecules could have important therapeutic applications. This study reports the investigation of a DNA-binding pyrrole-imidazole polyamide targeted to bind the DNA sequence 5M-bM-^@M-^Y-WGGWWW-3M-bM-^@M-^Y with reference to its potency in a subcutaneous xenograft...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-40218 | biostudies-arrayexpress
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