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ProteomicsProteome / pYome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030582 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
ProteomicsRewiring of B cell receptor signaling by Epstein-Barr virus LMP2A
Epstein-Barr virus (EBV) infects human B cells and reprograms them to allow virus replication and persistence. One key viral factor in this process is latent membrane protein 2A (LMP2A), which has been described as a B cell receptor (BCR) mimic promoting malignant transformation. However, how LMP2A ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-09-22 | PXD018566 | Pride
B cell receptor Signal transduction Lymphoma Epstein-barr virus 
ProteomicsActivation of CD44 / AKT signaling promotes resistance to FGFR1 inhibition in squamous cell lung cancer
Lung cancer is the leading cause of cancer related deaths, worldwide. Fibroblast growth factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially targetable genetic alterations in squamous cell lung cancer (SQCLC). Highly selective tyrosine kinase inhibitors have been...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025389 | Pride
Cd44 Akt Mass spectrometry Phosphoproteomics Lung cancer Fgfr1 
ProteomicsAML_profiling - Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome and tyrosine-phosphatome in acute myeloid leukemia
LC-MS/MS was used to profile total phosphotyrosine phosphatase in acute myeloid leukemia (AML) in order to find potential biomarkers, drug targets, signatures for AML classification, and its relationship with total phosphotyrosine amount in the samples.
ORGANISM(S): Homo sapiens (Human) 
2017-02-16 | PXD001170 | Pride
Pyome Ptpome Acute myeloid leukemia Proteome Aml Lc-ms/ms 
ProteomicsSHMT2 controls Burkitt lymphoma cell survival by maintaining an oncogenic TCF3 transcriptional program
In this study, the human Burkitt’s Lymphoma cell line BL60 has been analysed via proteomic and phosphoproteomic analysis for effect of a knock down of the serine hydroxymethyltransferase 2 (shSHMT2) compared to a control construct (shGL2). Concerning the phosphoproteome, these results have been comp...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD018961 | Pride
B cell receptor One carbon metabolism Burkitt’s lymphoma 
ProteomicsMolecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
Prednisone is anti-inflammatory glucocorticoid (GC), and GC-based therapy is most used combination chemotherapy for treating aggressive B-cell lymphomas. However, there are still gaps in our understanding of specific mechanism of GC’s action for its cytotoxicity. By performing multi-omics approac...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD041891 | Pride
Lymphoma Glucocorticoid receptor (gr) Bcr signaling B cells 
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