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This project aims to uncover the co-option and preservation of ancient proteins through the process of sclerite development in deep-sea creature Chrysomallon Squamiferum. Proteomes of the evolutionarily novel hard part, the sclerite and the long conserved spirial shell were studied, in comparison to...
ORGANISM(S): Chrysomallon squamiferum Gigantopelta aegis 
2025-05-06 | PXD051659 | Pride
High-content screening (HCS) has become a powerful tool in drug discovery; however, their reliance on indirect readouts and surrogate markers limits their ability to directly assess drug-protein interactions at endogenous levels, particularly in subcellular contexts. Here, we report the development ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD059271 | Pride
Alternative open reading frames (AltORFs) are unannotated sequences in genome that encode novel peptides or proteins named alternative proteins (AltProts). Although ribosome profiling and bioinformatics predict a large number of AltProts, mass spectrometry (MS) as the only direct way of identificati...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-23 | PXD033940 | Pride
A recent study reported that daptomycin-resistant MRSA (DAPR) strain biofilm is more resistant to daptomycin and vancomycin, as compared to the WT strain biofilm. This pose a great danger since DAPR MRSA is prevalent in clinics and they often form biofilms in medical devices. In this study, we inves...
ORGANISM(S): Staphylococcus aureus 
2021-11-11 | PXD024005 | Pride
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