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ProteomicsSalivary Protein Biomarker Detection of Saliva Secretion Disorder in a Primary Sjögren Syndrome Murine Model
Decreased salivary flow is one of the most common symptoms in primary Sjögren syndrome (pSS). The present study was designed to identify a salivary protein biomarker related to saliva secretion disorder in NOD/ShiLtJ mice, a pSS primary murine model. The stimulated saliva was collected from NOD/ShiL...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-21 | PXD008199 | Pride
Biomarker  saliva secretion disorder  sjögren syndrome  saliva  differential proteomic analysis 
TranscriptomicsA Y-chromosome-encoded small RNA acts as sex determinant in persimmons
In plants, multiple lineages have evolved sex chromosomes independently, providing a powerful comparative framework, but few specific determinants controlling the expression of a specific sex have been identified. We investigated sex-determinants in Caucasian persimmon, Diospyros lotus, a dioecious ...
ORGANISM(S): Diospyros lotus 
2014-11-04 | E-GEOD-61386 | biostudies-arrayexpress
ProteomicsUSP20 promotes T-ALL evolution by deubiquitinating modified HIF1A
Qualitative analysis of proteome is to study the types and quantities of proteome identified by samples under different conditions, and to perform functional analysis of the identified proteins, so as to provide reference information for quantitative and modification analysis of high-throughput prot...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD053080 | Pride
Usp20 Hif1a 
MetabolomicsDynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy

OBJECTIVES: High activity of Indoleamine 2,3-dioxygenase1 (IDO1) in lung cancer patients converts tryptophan (Trp), which is the essential amino acid for T cell metabolism, to kynurenine (Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamics...

2022-08-05 | MTBLS5267 | MetaboLights
UnknownNeuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity.
Not available
S-EPMC8490515 | biostudies-literature
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
UnknownCytotoxic T-Cell Trafficking Chemokine Profiles Correlate With Defined Mucosal Microbial Communities in Colorectal Cancer.
Not available
S-EPMC8442671 | biostudies-literature
UnknownMEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB.
Not available
S-EPMC11496645 | biostudies-literature
ProteomicsDeubiquitinase JOSD2 promotes non-small cell lung cancer proliferation via deubiquitylation and inactivation of LKB1
Deubiquitinases (DUBs), frequently overactivated in cancers, are associated with tumorigenesis and regarded as promising therapeutic targets. However, the underlying mechanism of DUBs promoting non-small cell lung cancer (NSCLC) are poorly understood. Through a global analysis of the contribution of...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046139 | Pride
Deubiquitinases K6-linked polyubiquitination Non-small cell lung cancer Lkb1 Kinase activity Josd2 
UnknownDoubleSG-DTA: Deep Learning for Drug Discovery: Case Study on the Non-Small Cell Lung Cancer with EGFRT790M Mutation.
Not available
S-EPMC9965659 | biostudies-literature
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